{"id":66,"date":"2018-01-08T10:14:45","date_gmt":"2018-01-08T10:14:45","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/?page_id=66"},"modified":"2023-10-05T12:41:42","modified_gmt":"2023-10-05T12:41:42","slug":"patch-clamp","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/laboratoria\/patch-clamp\/","title":{"rendered":"Elektrofyziol\u00f3gia"},"content":{"rendered":"<h2><span class=\"H3\">Patch clamp zosil\u0148ova\u010de Axopatch 200-B (Axon Instruments), VE-2 (Alembic Instruments), stimul\u00e1tor IonOptix MYOPACER, trha\u010dka mikropipiet P-97 (Sutter Instruments) <\/span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Nasp\u00e4\u0165<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<h3>Kontakt: RNDr. Ivan Zahradn\u00edk, CSc.<\/h3>\n<h3 style=\"line-height:1.3\">Vybudovan\u00e9 s podporou projektov <a href=\"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/nih-firca-ro3-tw005543-2\/\">NIH FIRCA RO3 TW005543\/2<\/a>, <a href=\"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/lshm-ct-2005-018802\/\">LSHM-CT-2005-018802<\/a> a <a href=\"https:\/\/www.umfg.sav.sk\/vyskum\/projekty\/infrastrukturne-projekty\/itms-26240120008\/\" >ITMS 26240120008<\/a><\/h3>\n<p>Met\u00f3da <b>&#8222;patch clamp&#8220;<\/b> sa pou\u017e\u00edva hlavne na meranie<\/p>\n<ul style=\"line-height:1.2\">\n<li>v\u00e1pnikov\u00fdch pr\u00fadov na izolovan\u00fdch \u017eiv\u00fdch srdcov\u00fdch myocytoch pomocou met\u00f3dy nap\u00e4\u0165ov\u00e9ho z\u00e1mku<\/li>\n<li>aplik\u00e1ciu indik\u00e1torov, pufrov a metabolitov do cytozolu srdcov\u00fdch myocytov<\/li>\n<li>stimul\u00e1ciu srdcov\u00fdch myocytov na vyvolanie lok\u00e1lneho uvo\u013enenia v\u00e1pnika<\/li>\n<li>meranie pas\u00edvnych elektrick\u00fdch vlastnost\u00ed buniek (kapacita a odpor membr\u00e1ny) s vysokou citlivos\u0165ou a \u010dasov\u00fdm rozl\u00ed\u0161en\u00edm<\/li>\n<\/ul>\n<table width=\"100%\">\n<tbody >\n<tr>\n<td><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-555 aligncenter\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/perfusion-300x199-300x199.jpg\" alt=\"perfusion\" width=\"206\" height=\"137\" \/><\/td>\n<td><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-556 aligncenter\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/patch-clamp-300x198-300x198.jpg\" alt=\"patch clamp\" width=\"207\" height=\"137\" \/><\/td>\n<td><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-562 aligncenter\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/cell3-300x198-300x198.png\" alt=\"cell3\" width=\"206\" height=\"136\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"line-height:1.3\">Zauj\u00edmame sa o modul\u00e1ciu aktiv\u00e1cie a inaktiv\u00e1cie v\u00e1pnikov\u00fdch pr\u00fadov cez L-typ v\u00e1pnikov\u00fdch kan\u00e1lov za r\u00f4znych podmienok a o zmeny v\u00e1pnikov\u00fdch pr\u00fadov vyvolan\u00e9 fyziologick\u00fdmi a patologick\u00fdmi podnetmi.<\/p>\n<p style=\"line-height:1.3\">Met\u00f3da <b>&#8222;field stimulation&#8220;<\/b> sa pou\u017e\u00edva na stimul\u00e1ciu buniek extern\u00fdmi elektr\u00f3dami. Zauj\u00edmame sa o zmeny uvo\u013e\u0148ovania v\u00e1pnika vyvolan\u00e9 fyziologick\u00fdmi a patologick\u00fdmi podnetmi.<\/p>\n<p style=\"line-height:1.3\">Meranie <b>membr\u00e1novej kapacity s vysokou rozli\u0161ovacou schopnos\u0165ou<\/b> sa pou\u017e\u00edva ako n\u00e1stroj na \u0161t\u00fadium dynamiky povrchovej membr\u00e1ny a t-tubulov v srdcov\u00fdch myocytoch.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Patch clamp zosil\u0148ova\u010de Axopatch 200-B (Axon Instruments), VE-2 (Alembic Instruments), stimul\u00e1tor IonOptix MYOPACER, trha\u010dka mikropipiet P-97 (Sutter Instruments) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Nasp\u00e4\u0165 Kontakt: RNDr. Ivan Zahradn\u00edk, CSc. Vybudovan\u00e9&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/laboratoria\/patch-clamp\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":18,"menu_order":40,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/66"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/comments?post=66"}],"version-history":[{"count":22,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/66\/revisions"}],"predecessor-version":[{"id":2521,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/66\/revisions\/2521"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/18"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/media?parent=66"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}