{"id":467,"date":"2018-01-10T13:42:34","date_gmt":"2018-01-10T13:42:34","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/?page_id=467"},"modified":"2023-10-06T14:32:57","modified_gmt":"2023-10-06T14:32:57","slug":"apvt-51-031104","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/apvt-51-031104\/","title":{"rendered":"APVT-51-031104"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>Mechanizmus v\u00e4zby excit\u00e1cie s kontrakciou v norm\u00e1lnom a zlyh\u00e1vaj\u00facom myokarde cicavcov &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Nasp\u00e4\u0165<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Ved\u00faci projektu: <a href=\"https:\/\/confolab.sav.sk\/ovsb\/pracovnici\/vyskumnici\/rndr-ivan-zahradnik-csc\/\">Ivan Zahradn\u00edk<\/a><\/h3>\n<h3>Trvanie: janu\u00e1r 2005 &#8211; december 2007<br \/>\nKoordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej fyziol\u00f3gie a genetiky SAV, Bratislava<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Anot\u00e1cia:<\/span><\/h3>\n<p>V\u00e4zba excit\u00e1cie s kontrakciou v srdcov\u00fdch myocytoch cicavcov je sprostredkovan\u00e1 v\u00e1pnikovou signaliz\u00e1ciou v tubulo-retikul\u00e1rnom spojen\u00ed, ktor\u00e1 zah\u0155\u0148a vtok v\u00e1pnika z vonkaj\u0161ieho prostredia, uvo\u013enenie v\u00e1pnika zo sarkoplazmatick\u00e9ho retikula, a inaktiv\u00e1ciu oboch procesov. V zlyh\u00e1vaj\u00facom srdci je kontraktilita kardiomyocytov naru\u0161en\u00e1 v d\u00f4sledku zn\u00ed\u017een\u00e9ho uvo\u013e\u0148ovania v\u00e1pnika. Cie\u013eom predlo\u017een\u00e9ho projektu je zisti\u0165 vz\u0165ah medzi organiz\u00e1ciou tubulo-retikul\u00e1rneho spojenia a v\u00e1pnikovou signaliz\u00e1ciou v norm\u00e1lnom a zlyh\u00e1vaj\u00facom srdci. Vyu\u017eijeme na\u0161e osved\u010den\u00e9 metodologick\u00e9 a teoretick\u00e9 pr\u00edstupy (meranie \u010dist\u00fdch v\u00e1pnikov\u00fdch pr\u00fadov a lok\u00e1lnych v\u00e1pnikov\u00fdch sign\u00e1lov, stereologick\u00e1 identifik\u00e1cia prostredia organel, modelovanie reak\u010dno-dif\u00faznych procesov, simul\u00e1cia aktivity v\u00e1pnikov\u00fdch kan\u00e1lov tubulo-retikul\u00e1rneho spojenia a geometrick\u00e9 modelovanie), umo\u017e\u0148uj\u00face charakterizova\u0165 organiz\u00e1ciu tubulo-retikul\u00e1rneho spojenia a v\u00e1pnikov\u00fa signaliz\u00e1ciu medzi v\u00e1pnikov\u00fdmi kan\u00e1lmi.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">K\u013e\u00fa\u010dov\u00e9 slov\u00e1:<\/span><\/h3>\n<p>myokard, myocyt, v\u00e1pnikov\u00e1 signaliz\u00e1cia, i\u00f3nov\u00e9 kan\u00e1ly, kontraktilita, srdcov\u00e9 zlyhanie<\/td>\n<\/tr>\n<tr>\n<td><span class=\"H3\">Ciele:<\/span>V\u00e4zba excit\u00e1cie s kontrakciou v srdcovom svale cicavcov je zalo\u017een\u00e1 na v\u00e1pnikovej signaliz\u00e1cii v tubulo-retikul\u00e1rnom spojen\u00ed. Na\u0161a z\u00e1kladn\u00e1 hypot\u00e9za je, \u017ee \u0161pecifick\u00e1 mikroarchitekt\u00fara tubulo-retikul\u00e1rneho spojenia pozost\u00e1vaj\u00faceho z aponovan\u00fdch klastrov DHPR a RyR kan\u00e1lov, spolu s ich \u0161pecifick\u00fdmi Ca-z\u00e1visl\u00fdmi vr\u00e1tkovac\u00edmi vlastnos\u0165ami, d\u00e1va procesu v\u00e4zby excit\u00e1cie s kontrakciou v srdcov\u00fdch myocytoch charakteristick\u00e9 vlastnosti. Formul\u00e1cia tejto hypot\u00e9zy vy\u00fastila do konceptu jednotky v\u00e4zby excit\u00e1cie s kontrakciou (ECCU). ECCU je ch\u00e1pan\u00e1 ako kompletn\u00e1 mno\u017eina kan\u00e1lov v  diadickom spojen\u00ed (excita\u010dn\u00e1 jednotka \u2013 EU \u2013 zlo\u017een\u00e1 z DHPR kan\u00e1lov, a Ca-uvo\u013e\u0148uj\u00faca jednotka \u2013 RU \u2013 zlo\u017een\u00e1 z RyR kan\u00e1lov), definovan\u00e1 vodivostn\u00fdmi a vr\u00e1tkovac\u00edmi vlastnos\u0165ami, topol\u00f3giou a i\u00f3nov\u00fdm prostred\u00edm z\u00fa\u010dastnen\u00fdch kan\u00e1lov. Cie\u013eom tohto projektu je definova\u0165 \u00falohu zmien mikroarchitekt\u00fary srdcov\u00fdch svalov\u00fdch buniek, teda vlastnost\u00ed ECCU a ich distrib\u00facie, v naru\u0161enej efekt\u00edvnosti uvo\u013e\u0148ovania v\u00e1pnika v zlyh\u00e1vaj\u00facom srdci. Na dosiahnutie tohto cie\u013ea budeme vyu\u017e\u00edva\u0165 viacer\u00e9 p\u00f4vodn\u00e9 met\u00f3dy vyvinut\u00e9 v na\u0161ich laborat\u00f3ri\u00e1ch, menovite model kinetiky v\u00e1pnikov\u00e9ho pr\u00fadu s inaktiv\u00e1ciou z\u00e1vislou na uvo\u013enen\u00ed v\u00e1pnika (RZI), software na simul\u00e1ciu elektrofyziologick\u00e9ho experimentu zalo\u017een\u00fd na simul\u00e1cii interakcie klastrov kan\u00e1lov, techniku selekt\u00edvnej indukcie RZI v\u00e1pnikov\u00e9ho pr\u00fadu,  modelovanie reak\u010dno-dif\u00faznych procesov v di\u00e1de, stereologick\u00fa identifik\u00e1ciu prostredia organel a geometrick\u00e9 modelovanie svalov\u00fdch buniek. S\u00fastred\u00edme sa na dva \u00fazko nadv\u00e4zuj\u00face \u0161pecifick\u00e9 ciele: (1) Testova\u0165 hypot\u00e9zu, \u017ee zn\u00ed\u017een\u00e1 \u00fa\u010dinnos\u0165 a spo\u013eahlivos\u0165 v\u00e1pnikom indukovan\u00e9ho uvo\u013enenia v\u00e1pnika v zlyh\u00e1vaj\u00facom srdci je sp\u00f4soben\u00e1 zmenami ECCU; (2) Testova\u0165 hypot\u00e9zu, \u017ee zmeny v uvo\u013e\u0148ovan\u00ed v\u00e1pnika v zlyh\u00e1vaj\u00facich myocytoch s\u00fa sp\u00f4soben\u00e9 zmenami v organiz\u00e1cii ECCU jednotiek v bunke.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publik\u00e1cie:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20548054\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1114\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JGP-125x150.jpg\" alt=\"JGP\" width=\"75\" height=\"98\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Valent I<\/strong>, <strong>Zahradnik I<\/strong> (2010): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20548054\")'>Frequency and release flux of calcium sparks in rat cardiac myocytes: a relation to RYR gating.<\/a> <i> J Gen Physiol<\/i> 136: 101-116.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19399440\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1117\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/SystemsBiol-150x150.jpg\" alt=\"SystemsBiol\" width=\"75\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\"><strong>Parulek J<\/strong>, Sramek M, Cerveansky M, <strong>Novotova M<\/strong>, <strong>Zahradnik I<\/strong> (2009). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=19399440\")'>A cell architecture modeling system based on quantitative ultrastructural characteristics.<\/a><i> Methods Mol Biol.<\/i> 500: 289-312.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/apps.webofknowledge.com\/full_record.do?product=WOS&#038;search_mode=GeneralSearch&#038;qid=3&#038;SID=P2dIMd78gWsTxG6vmMi&#038;page=1&#038;doc=6\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1129\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/book2-150x150.jpg\" alt=\"book2\" width=\"75\" height=\"113\" \/><\/a><\/td>\n<td class=\"two\"><strong>Parulek J<\/strong>, Sramek M,<strong> Zahradnik I<\/strong> (2009). <a href='javascript:launchRemote(\"https:\/\/apps.webofknowledge.com\/InboundService.do?product=WOS&#038;SID=V1gWOyagsDVafQ1Qes6&#038;UT=WOS%3A000276792200002&#038;SrcApp=EndNote&#038;DestFail=http%3A%2F%2Fwww.webofknowledge.com&#038;action=retrieve&#038;Init=Yes&#038;SrcAuth=ResearchSoft&#038;Func=Frame&#038;customersID=ResearchSoft&#038;IsProductCode=Yes&#038;mode=FullRecord\")'>GeomCell Design of Cell Geometry.<\/a><i> Recent Advances in the 3d Physiological Human, N. Magnenat-Thalmann et al. (eds.), Springer-Verlag London Ltd, <\/i> p. 21-36.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18591191\")'><img decoding=\"async\" class=\"alignnone wp-image-1118\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JPhysiol.jpg\" alt=\"JPhysiol\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"><strong>Polakova E<\/strong>,<strong> Zahradnikova A Jr<\/strong>, <strong>Pavelkova J<\/strong>, <strong>Zahradnik I<\/strong>, <strong>Zahradnikova A<\/strong> (2008). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18591191\")'>Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes.<\/a><i> J Physiol.<\/i> 586: 3839-3854.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18048694\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1119\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JPharmExpTher.jpg\" alt=\"JPharmExpTher\" width=\"75\" height=\"98\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnik I<\/strong>, <strong>Minarovic I<\/strong>, <strong>Zahradnikova A<\/strong> (2008). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18048694\")'>Inhibition of the cardiac L-type calcium channel current by antidepressant drugs.<\/a><i> J Pharmacol Exp Ther.<\/i> 324:977-984.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17327449?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1118\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/Diabetes.png\" alt=\"JPhysiol\" width=\"75\" height=\"99\" \/><\/a><\/td>\n<td class=\"two\">Ath\u00e9a Y, Viollet B, Mateo P, Rousseau D, <strong>Novotova M<\/strong>, Garnier A, Vaulont S, Wilding JR, Grynberg A, Veksler V, Hoerter J, Ventura-Clapier R. (2007): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17327449?dopt=Citation\")'>AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function.<\/a><i> Diabetes.<\/i> 586: 786-794.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17390540?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1118\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/BioTechniques.jpg\" alt=\"Biotechniques\" width=\"75\" height=\"99\" \/><\/a><\/td>\n<td class=\"two\"><strong>Novak P<\/strong>, <strong>Gaburjakova M<\/strong>, <strong>Zahradnik I<\/strong> (2007): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17390540?dopt=Citation\")'>BLM Analyzer: a software tool for experiments on planar lipid bilayers.<\/a><i> Biotechniques.<\/i> 42: 335-336, 338-339, 341.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17034755?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1113\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0005273606X07319-cov150h.gif\" alt=\"JPhysiol3\" width=\"75\" height=\"95\" \/><\/a><\/td>\n<td class=\"two\"><strong>Valent I<\/strong>, <strong>Zahradnikova A<\/strong>, <strong>Pavelkova J<\/strong>, <strong>Zahradnik I<\/strong> (2007): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17034755?dopt=Citation\")'>Spatial and temporal Ca2+, Mg2+, and ATP(2-) dynamics in cardiac dyads during calcium release.<\/a><i> Biochim Biophys Acta-Biomembr.<\/i> 1768: 155-166.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"httsp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17475903?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1113\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JPharmExpTher-77x100.jpg\" alt=\"JPhysiol3\" width=\"75\" height=\"95\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Minarovic I<\/strong>, <strong>Zahradnik I<\/strong> (2007): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17475903?dopt=Citation\")'>Competitive and cooperative effects of bay k8644 on the L-type calcium channel current inhibition by calcium channel antagonists.<\/a><i> J Pharmacol Exp Ther.<\/i> 322: 638-645.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17124272\")'><img decoding=\"async\" class=\"alignnone wp-image-1113\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JPhysiol3.jpg\" alt=\"JPhysiol3\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A Jr<\/strong>, <strong>Polakova E<\/strong>, <strong>Zahradnik I<\/strong>, <strong>Zahradnikova A<\/strong> (2007). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17124272\")'>Kinetics of calcium spikes in rat cardiac myocytes.<\/a><i> J Physiol<\/i> 578: 677-691.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16786392?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1113\" src=\"https:\/\/static-content.springer.com\/cover\/journal\/10439\/34\/7.jpg\" alt=\"JPhysiol3\" width=\"75\" height=\"95\" \/><\/a><\/td>\n<td class=\"two\"><strong>Novak P<\/strong>, <strong>Zahradnik I<\/strong> (2006): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16786392?dopt=Citation\")'>Q-method for high-resolution, whole-cell patch-clamp impedance measurements using square wave stimulation.<\/a><i> Ann Biomed Eng.<\/i> 34: 1201-1212.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16308428?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/GPB.jpg\" width=\"75\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\"><strong>Novak P<\/strong>, <strong>Zahradnik I<\/strong> (2005): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16308428?dopt=Citation\")'>Computer-aided formation of the whole-cell patch-clamp recording configuration.<\/a><i> Gen Physiol Biophys.<\/i> 24: 337-348.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16260840?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1114\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JGP-125x150.jpg\" alt=\"JGP\" width=\"75\" height=\"98\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnik I<\/strong>, Gyorke S, <strong>Zahradnikova A<\/strong> (2005). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16260840?dopt=Citation\")'>Calcium activation of ryanodine receptor channels&#8211;reconciling RyR gating models with tetrameric channel structure.<\/a><i> J Gen Physiol.<\/i> 126: 515-527.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Mechanizmus v\u00e4zby excit\u00e1cie s kontrakciou v norm\u00e1lnom a zlyh\u00e1vaj\u00facom myokarde cicavcov &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Nasp\u00e4\u0165 Ved\u00faci projektu: Ivan Zahradn\u00edk Trvanie: janu\u00e1r 2005 &#8211; december 2007 Koordinuj\u00faca organiz\u00e1cia: \u00dastav&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/apvt-51-031104\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":117,"menu_order":235,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/467"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/comments?post=467"}],"version-history":[{"count":9,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/467\/revisions"}],"predecessor-version":[{"id":2604,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/467\/revisions\/2604"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/117"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/media?parent=467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}