{"id":395,"date":"2018-01-10T08:20:26","date_gmt":"2018-01-10T08:20:26","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/?page_id=395"},"modified":"2023-10-06T12:55:30","modified_gmt":"2023-10-06T12:55:30","slug":"apvv-0721-10","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/apvv-0721-10\/","title":{"rendered":"APVV-0721-10"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>Remodelovanie myokardu &#8211; \u00faloha v\u00e1pnikovej signaliz\u00e1cie (REMOD) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Nasp\u00e4\u0165<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Ved\u00faci projektu: <a href=\"https:\/\/confolab.sav.sk\/ovsb\/pracovnici\/vyskumnici\/ing-alexandra-zahradnikova-drsc\/\">Alexandra Zahradn\u00edkov\u00e1<\/a><\/h3>\n<h3>Trvanie: m\u00e1j 2011 &#8211; okt\u00f3ber 2014<br \/>\nKoordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej fyziol\u00f3gie a genetiky SAV, Bratislava<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Anot\u00e1cia:<\/span><\/h3>\n<p>Srdcov\u00e9 zlyhanie je d\u00f4sledkom dlhodob\u00fdch patologick\u00fdch procesov, pri ktor\u00fdch doch\u00e1dza k \u0161pecifick\u00fdm poruch\u00e1m, sprev\u00e1dzan\u00fdm aktiv\u00e1ciou kompenza\u010dn\u00fdch mechanizmov. Spolo\u010dn\u00fdm znakom, pravdepodobne v d\u00f4sledku konvergencie mnoh\u00fdch regula\u010dn\u00fdch mechanizmov, s\u00fa zmeny v\u00e1pnikovej signaliz\u00e1cie kardiomyocytov. Predmetom predlo\u017een\u00e9ho projektu s\u00fa poruchy v\u00e1pnikovej signaliz\u00e1cie v rann\u00fdch f\u00e1zach po\u0161kodenia myokardu s d\u00f4razom na \u00falohu \u00fastredn\u00e9ho prote\u00ednu v\u00e1pnikovej signaliz\u00e1cie v kardiomyocytoch &#8211; ryanod\u00ednov\u00e9ho receptora (RYR2). Metodol\u00f3gia je zalo\u017een\u00e1 na porovnan\u00ed vlastnost\u00ed v\u00e1pnikovej signaliz\u00e1cie a mikroarchitekt\u00fary myocytov izolovan\u00fdch z myokardu potkanov vystaven\u00fdch stresov\u00fdm stimulom. Modelom fyziologicky remodelovan\u00e9ho myokardu bude myokard adaptovan\u00fd na spont\u00e1nnu fyzick\u00fa aktivitu (behanie ad libitum). Modelom po\u0161koden\u00e9ho myokardu bude myokard po vysokej jednorazovej d\u00e1vke izoproterenolu, ktor\u00fd m\u00e1 znaky bl\u00edzke infarktu myokardu, a myokard po vysokej jednorazovej d\u00e1vke streptozotoc\u00ednu, ktor\u00fd m\u00e1 znaky bl\u00edzke diabetick\u00e9mu myokardu. \u00da\u010dinnos\u0165 stresov\u00fdch stimulov na remodelovanie myokardu bude u ka\u017ed\u00e9ho jedinca verifikovan\u00e1. Porovnanie s myocytmi myokardu adaptovan\u00e9ho na sedat\u00edvny re\u017eim umo\u017en\u00ed zisti\u0165 rozsah fyziologickej a patologickej variability parametrov v\u00e1pnikovej signaliz\u00e1cie. Projekt umo\u017en\u00ed identifikova\u0165 molekulov\u00e9 a bunkov\u00e9 faktory ur\u010duj\u00face funkciu RYR2v remodelovanom myokarde a dedukova\u0165 kritick\u00e9 miesta po\u0161kodenia v\u00e1pnikovej signaliz\u00e1cie.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">K\u013e\u00fa\u010dov\u00e9 slov\u00e1:<\/span><\/h3>\n<p>Zlyhanie srdca, po\u0161kodenie myokardu, kardiomyocyt, v\u00e1pnikov\u00e1 signaliz\u00e1cia, ryanod\u00ednov\u00fd receptor<\/td>\n<\/tr>\n<tr>\n<td><span class=\"H3\">Ciele:<\/span>Cie\u013eom projektu je objasni\u0165 \u00falohu molekul\u00e1rnych a bunkov\u00fdch faktorov systolickej a diastolickej v\u00e1pnikovej signaliz\u00e1cie v skor\u00fdch \u0161t\u00e1di\u00e1ch adapt\u00e1cie kardiomyocytov na stresov\u00e9 stimuly ved\u00face k remodelovaniu myokardu. Cie\u013e dosiahneme sledovan\u00edm aktivity RyR2 prostredn\u00edctvom spont\u00e1nnych a evokovan\u00fdch v\u00e1pnikov\u00fdch z\u00e1bleskov, sledovan\u00edm aktivity izolovan\u00fdch RyR2 a sledovan\u00edm mikroarchitekt\u00fary myocytov na experiment\u00e1lnych modeloch po\u0161kodenia myokardu.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">V\u00fdsledky:<\/span><\/h3>\n<p>Projekt bol zameran\u00fd na \u0161t\u00fadium v\u00e1pnikovej signaliz\u00e1cie a relevantnej mikroarchitekt\u00fary myocytov po\u010das adapt\u00e1cie myokardu na fyziologick\u00fa a patofyziologick\u00fa z\u00e1\u0165a\u017e.<\/p>\n<ul>\n<li>Podali sme experiment\u00e1lny d\u00f4kaz, podporen\u00fd teoretickou anal\u00fdzou, \u017ee pri elektrickej stimul\u00e1cii sa aktivuje len mal\u00e1 \u010das\u0165 z celkov\u00e9ho po\u010dtu RyR2 kan\u00e1lov v myocyte. Tento v\u00fdsledok otvoril nov\u00fd poh\u013ead na regul\u00e1ciu intenzity a r\u00fdchlosti kontrakcie myocytu prostredn\u00edctvom regul\u00e1cie podielu RyR2 zapojen\u00fdch do uvo\u013e\u0148ovania v\u00e1pnika.<\/li>\n<li>Experiment\u00e1lne sme ur\u010dili rozsah priamej regul\u00e1cie aktivity RyR2 kan\u00e1lov i\u00f3nmi v\u00e1pnika, hor\u010d\u00edka a ATP z cytozolickej strany a i\u00f3nmi v\u00e1pnika z lumin\u00e1lnej strany RyR2 v koncentra\u010dnom rozsahu pokr\u00fdvaj\u00facom fyziologick\u00e9 a\u017e patofyziologick\u00e9 podmienky.<\/li>\n<li>Ur\u010dili sme polohu v\u00e4zbov\u00e9ho miesta pre fosfoprote\u00edn fosfat\u00e1zu I, ktor\u00e9 hr\u00e1 v\u00fdznamn\u00fa \u00falohu pri regul\u00e1cii funkcie RyR2, v molekulovej \u0161trukt\u00fare ryanod\u00ednov\u00e9ho receptora.<\/li>\n<li>Objasnili sme vz\u0165ah \u0161trukt\u00fary diadick\u00fdch spojen\u00ed ku kvalite v\u00e1pnikovej signaliz\u00e1cie. Uk\u00e1zali sme \u017ee remodelovanie myokardu vystaven\u00e9ho patofyziologickej z\u00e1\u0165a\u017ei sa prejav\u00ed na remodelovan\u00ed siete vn\u00fatorn\u00e9ho membr\u00e1nov\u00e9ho syst\u00e9mu myocytov a zhor\u0161en\u00ed kvality v\u00e1pnikovej signaliz\u00e1cie.<\/li>\n<\/ul>\n<p>Identifikovali a charakterizovali sme hlavn\u00e9 molekulov\u00e9 a bunkov\u00e9 faktory ur\u010duj\u00face funkciu syst\u00e9mu v\u00e1pnikovej signaliz\u00e1cie srdcov\u00fdch myocytov v ranej f\u00e1ze rozvoja zlyhania myokardu a preuk\u00e1zali ich spolu\u00fa\u010das\u0165 na remodelovan\u00ed myokardu. V\u00fdsledky \u0161t\u00fadie umo\u017e\u0148uj\u00fa porozumie\u0165 v\u00e1pnikovej signaliz\u00e1cii v srdcov\u00fdch myocytoch zdrav\u00e9ho a experiment\u00e1lne za\u0165a\u017een\u00e9ho myokardu. Z\u00edskan\u00e9 poznatky u\u013eah\u010dia identifik\u00e1ciu patologick\u00fdch zmien v \u0161trukt\u00fare a funkcii srdcov\u00fdch myocytov pri vroden\u00fdch aj z\u00edskan\u00fdch poruch\u00e1ch funkcie RYR2 a s nimi s\u00favisiacich arytmi\u00ed, n\u00e1hlej srdcovej smrti a zlyh\u00e1vania srdca.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publik\u00e1cie:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32415205\")'><img decoding=\"async\" width=\"75\" class=\"alignnone wp-image-1110\" alt=\"SciRep\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/SciRep-1-300x111.jpg\"><\/a><\/td>\n<td class=\"two\"><strong>Novotova M<\/strong>, <strong>Zahradnikova A Jr<\/strong>, Nichtova Z, Kovac R, Kralova E, Stankovicova T, <strong>Zahradnikova A<\/strong>, <strong>Zahradnik I<\/strong> (2020): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32415205\")'>Structural variability of dyads relates to calcium release in rat ventricular myocytes<\/a>. <i>Sci Rep<\/i> 10: 8076 doi: 10.1038\/s41598-020-64840-5.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23741324\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1110\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/PLoSOne.jpg\" alt=\"PLoSOne\" width=\"75\" height=\"54\" \/><\/a><\/td>\n<td class=\"two\"><strong>Hotka M<\/strong>, <strong>Zahradnik I<\/strong> (2017): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29166646\")'>Reconstruction of membrane current by deconvolution and its application to membrane capacitance measurements in cardiac myocytes<\/a>. <i>PLoS One<\/i> 12: e0188452.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28713282\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontiersPhysiol-150x51.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" height=\"17\" \/><\/a><\/td>\n<td class=\"two\"><strong>Faltinova A<\/strong>, Tomaskova N, Antalik M, Sevcik J, <strong>Zahradnikova A<\/strong> (2017). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28713282\")'>The N-terminal region of the ryanodine receptor affects channel activation<\/a>. <i>Front Physiol<\/i> 8: 443.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\" width=\"5%\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26009544\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1114\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JGP-125x150.jpg\" alt=\"JGP\" width=\"80\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\">Petrovic P, <strong>Valent I<\/strong>, <strong>Cocherova E<\/strong>, <strong>Pavelkova J<\/strong>, <strong>Zahradnikova A<\/strong> (2015): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26009544\")'>Ryanodine receptor gating controls generation of diastolic calcium waves in cardiac myocytes<\/a>. <i>J Gen Physiol<\/i> 145: 489-511.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25371090\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1138\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/Metallomics-150x150.jpg\" alt=\"Metallomics\" width=\"75\" height=\"100\" \/><\/a><\/td>\n<td class=\"two\">Huntosova V, Stroffekova K, Wagnieres G, <strong>Novotova M<\/strong>, <strong>Nichtova Z<\/strong>, Miskovsky P (2014): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25371090\")'>Endosomes: guardians against [Ru(Phen)] photo-action in endothelial cells during in vivo pO2 detection?<\/a> <i>Metallomics<\/i> 6: 2279-2289.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25372681\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1125\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/ActaCryst-150x150.jpg\" alt=\"ActaCryst\" width=\"75\" height=\"97\" \/><\/a><\/td>\n<td class=\"two\">Borko L, Bauerova-Hlinkova V, Hostinova E, Gasparik J, Beck K, Lai FA, <strong>Zahradnikova A<\/strong>, Sevcik J (2014): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25372681\")'>Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmia<\/a>s. <i>Acta Cryst<\/i> D70: 2897\u20132912.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/confolab.sav.sk\/sk\/Other\/2014_YBERC_Hotka.pdf\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1136\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/YBERC-150x150.jpg\" alt=\"YBERC\" width=\"75\" height=\"71\" \/><\/a><\/td>\n<td class=\"two\"><strong>Hotka M<\/strong>, <strong>Zahradnik I<\/strong> (2014):<a href='javascript:launchRemote(\"https:\/\/confolab.sav.sk\/sk\/Other\/2014_YBERC_Hotka.pdf\")'> Correction of the cross-talk error in cell membrane impedance analysis<\/a>. In: <i>YBERC 2014.<\/i> Bratislava, Slovak Republic. Proceedings of The 6th International Young Biomedical Engineers and Researchers Conference, July 2-4, 2014, p. 31-34. ISBN 978\u201380\u2013971697\u20130\u20131.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/confolab.sav.sk\/sk\/Other\/2014_ADEPT_Hotka.pdf\")'\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1137\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/Adept-150x147.jpg\" alt=\"Adept\" width=\"75\" height=\"33\" \/><\/a><\/td>\n<td class=\"two\"><strong>Hotka M<\/strong>, <strong>Zahradnik I<\/strong> (2014): <a href='javascript:launchRemote(\"https:\/\/confolab.sav.sk\/sk\/Other\/2014_ADEPT_Hotka.pdf\")'>High resolution measurement of electrical impedance of excitable cells.<\/a> In: <i>Adept 2014.<\/i> 2nd International Conference on Advances in Electronic and Photonic Technologies, Tatransk\u00e1 Lomnica, June 1-4, 2014, Proceedings of Adept, p. 55-58.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23741324\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1110\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/PLoSOne.jpg\" alt=\"PLoSOne\" width=\"75\" height=\"54\" \/><\/a><\/td>\n<td class=\"two\"><strong>Janicek R<\/strong>, <strong>Hotka M<\/strong>, <strong>Zahradnikova-Jr A<\/strong>, <strong>Zahradnikova A<\/strong>, <strong>Zahradnik I<\/strong> (2013): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23741324\")'>Quantitative analysis of calcium spikes in noisy fluorescent background<\/a>. <i>PLoS One<\/i> 8: e64394.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23675354\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontiersPhysiol-150x51.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" height=\"17\" \/><\/a><\/td>\n<td class=\"two\">Piquereau J, Caffin F, <strong>Novotova M<\/strong>, Lemaire C, Veksler V, Garnier A, Ventura-Clapier R, Joubert F (2013): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23675354\")'>Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?<\/a> <i>Front Physiol<\/i> 4: 102.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22934071\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontiersPhysiol-150x51.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" height=\"17\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Zahradnik I<\/strong> (2012). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22934071\")'>Construction of calcium release sites in cardiac myocytes<\/a>. <i>Front Physiol<\/i> 3: 322.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22890710\")'><img decoding=\"async\" class=\"alignnone wp-image-1113\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JPhysiol3.jpg\" alt=\"JPhysiol3\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"><strong>Janicek R<\/strong>, <strong>Zahradnikova-Jr A<\/strong>, <strong>Polakova E<\/strong>, <strong>Pavelkova J<\/strong>, <strong>Zahradnik I<\/strong>, <strong>Zahradnikova A<\/strong> (2012): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22890710\")'>Calcium spike variability in cardiac myocytes results from activation of small cohorts of RYR2 channels.<\/a> <i>J Physiol<\/i> 590: 5091-5106.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22851674\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1114\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JGP-125x150.jpg\" alt=\"JGP\" width=\"75\" height=\"98\" \/><\/a><\/td>\n<td class=\"two\"><strong>Tencerova B<\/strong>, <strong>Zahradnikova A<\/strong>, <strong>Gaburjakova J,<\/strong> <strong>Gaburjakova M<\/strong> (2012): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22851674\")'>Luminal Ca2+ controls activation of the cardiac ryanodine receptor by ATP<\/a>. <i>J Gen Physiol<\/i> 140: 93-108.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22781817\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/GPB.jpg\" width=\"75\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\"><strong>Nichtova Z<\/strong>, <strong>Novotova M<\/strong>, Kralova E, Stankovicova T (2012): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22781817\")'>Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol<\/a>. <i>Gen Physiol Biophys<\/i> 31: 141-51.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/cdn.intechopen.com\/pdfs-wm\/22502.pdf\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"https:\/\/cdn.intechopen.com\/books\/images\/1326.jpg\" width=\"75\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\">Bauerova-Hlinkova V,Bauer J, Hostinova E, Gasperik J, Beck K, Borko L, <strong> Faltinova A<\/strong>, <strong>Zahradnikova A<\/strong>, Sevcik J (2011): <a href='javascript:launchRemote(\"https:\/\/cdn.intechopen.com\/pdfs-wm\/22502.pdf\")'>Bioinformatics Domain Structure Prediction and Homology Modeling of Human Ryanodine Receptor 2.<\/a> Editor Mahmood A. Mahdavi. In Bioinformatics-Trends and Methodologies. &#8211; Rijeka, p. 325-352. ISBN 978-953-307-282-1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Remodelovanie myokardu &#8211; \u00faloha v\u00e1pnikovej signaliz\u00e1cie (REMOD) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Nasp\u00e4\u0165 Ved\u00faci projektu: Alexandra Zahradn\u00edkov\u00e1 Trvanie: m\u00e1j 2011 &#8211; okt\u00f3ber 2014 Koordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej fyziol\u00f3gie a genetiky&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/apvv-0721-10\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":117,"menu_order":150,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/395"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/comments?post=395"}],"version-history":[{"count":7,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/395\/revisions"}],"predecessor-version":[{"id":2566,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/395\/revisions\/2566"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/117"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/media?parent=395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}