{"id":387,"date":"2018-01-09T16:24:31","date_gmt":"2018-01-09T16:24:31","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/?page_id=387"},"modified":"2023-10-06T12:45:47","modified_gmt":"2023-10-06T12:45:47","slug":"vega-2-0110-15","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/vega-2-0110-15\/","title":{"rendered":"VEGA 2\/0110\/15"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>Vplyv z\u00e1\u0165a\u017ee myokardu na distrib\u00faciu vn\u00fatorn\u00e9ho membr\u00e1nov\u00e9ho syst\u00e9mu srdcov\u00fdch myocytov &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Nasp\u00e4\u0165<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Ved\u00faci projektu: <a href=\"https:\/\/confolab.sav.sk\/ovsb\/pracovnici\/vyskumnici\/rndr-marta-novotova-csc\/\">Marta Novotov\u00e1<\/a><\/h3>\n<h3>Trvanie: janu\u00e1r 2015 &#8211; december 2017<br \/>\nKoordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej fyziol\u00f3gie a genetiky SAV, Bratislava<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Anot\u00e1cia:<\/span><\/h3>\n<p>Srdcov\u00fd sval m\u00e1 schopnos\u0165 pru\u017enej adapt\u00e1cie na fyziologick\u00e9 potreby organizmu, ktor\u00e1 v\u0161ak zlyh\u00e1va pri patofyziologickej z\u00e1\u0165a\u017ei. Mechanizmy adapt\u00e1cie na \u00farovni srdcov\u00fdch myocytov nie s\u00fa dostato\u010dne spoznan\u00e9 a pochopen\u00e9. Cie\u013eom predlo\u017een\u00e9ho projektu je charakterizova\u0165 odpove\u010f vn\u00fatorn\u00e9ho membr\u00e1nov\u00e9ho syst\u00e9mu (endo\/sarko-plazmatick\u00e9 retikulum) srdcov\u00fdch myocytov na fyziologick\u00fa a patofyziologick\u00fa z\u00e1\u0165a\u017e. Met\u00f3dami elektr\u00f3novej a konfok\u00e1lnej fluorescen\u010dnej mikroskopie budeme sledova\u0165 distrib\u00faciu morfologicky rozdielnych dom\u00e9n hladkej a drsnej retikul\u00e1rnej siete (perinukle\u00e1rnej, perimyofibril\u00e1rnej a perimitochondri\u00e1lnej) myocytov \u013eavej komory a papil\u00e1rneho svalu myokardu potkana. Pomocou kvantitat\u00edvnej stereologickej anal\u00fdzy n\u00e1hodn\u00fdch obrazov n\u00e1hodn\u00fdch vzoriek tkaniva ur\u010d\u00edme zmeny v podiele a prostred\u00ed jednotliv\u00fdch retikul\u00e1rnych dom\u00e9n. Z\u00edskan\u00e9 \u00fadaje n\u00e1m umo\u017enia objasni\u0165 dopad remodelovania vn\u00fatorn\u00e9ho membr\u00e1nov\u00e9ho retikula na v\u00e1pnikov\u00fa signaliz\u00e1ciu a metabolizmus myocytov.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">K\u013e\u00fa\u010dov\u00e9 slov\u00e1:<\/span><\/h3>\n<p>srdcov\u00e9 myocyty, remodelovanie, retikulum, elektr\u00f3nov\u00e1 mikroskopia, morfol\u00f3gia, stereologick\u00e1 anal\u00fdza<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Ciele:<\/span><\/h3>\n<p>Hlavn\u00fdm cie\u013eom projektu je zisti\u0165 ako sa podie\u013ea vn\u00fatorn\u00fd membr\u00e1nov\u00fd syst\u00e9m (endo\/sarko-plazmatick\u00e9 retikulum) na remodelovan\u00ed \u0161trukt\u00fary myocytov pri zmene z\u00e1\u0165a\u017ee myokardu u cicavcov. Budeme sledova\u0165 zmeny objemovej hustoty, povrchovej hustoty a najbli\u017e\u0161ieho prostredia hladk\u00e9ho a drsn\u00e9ho retikul\u00e1rneho syst\u00e9mu v troch funk\u010dne odli\u0161n\u00fdch av\u0161ak syst\u00e9movo previazan\u00fdch dom\u00e9nach myocytu \u2013 v perimyofibril\u00e1rnej, perimitochondri\u00e1lnej a perinukle\u00e1rnej dom\u00e9ne. Z\u00edskan\u00e9 \u00fadaje umo\u017enia identifikova\u0165 a charakterizova\u0165 \u0161pecifick\u00e9 reakcie funk\u010dne \u0161pecializovan\u00fdch dom\u00e9n a foriem retikul\u00e1rnych membr\u00e1n a zisti\u0165 ich pr\u00edspevok k funk\u010dnej adapt\u00e1cii myocytov na r\u00f4zne formy z\u00e1\u0165a\u017ee.<\/p>\n<p>Porovnanie rozsahu a sp\u00f4sobu reakcie hladk\u00e9ho a drsn\u00e9ho retikul\u00e1rneho syst\u00e9mu s reakciou kontraktiln\u00fdch, energetick\u00fdch a proteosyntetick\u00fdch dom\u00e9n myocytu umo\u017en\u00ed identifikova\u0165 naru\u0161enie proporcionality v\u00fdvoja v r\u00e1mci a medzi funk\u010dne \u0161pecializovan\u00fdmi dom\u00e9nami myocytu.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publik\u00e1cie:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33134298\/\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontCellDevBiol.jpg\" alt=\"Front Cell Dev Biol\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"> Piquereau J, Veksler V, <strong>Novotova M<\/strong>, Ventura-Clapier R (2020): <a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33134298\/\")'>Energetic interactions between subcellular organelles in striated muscles<\/a>. <i>Front Cell Dev Biol<\/i> 8: 581045 doi: 10.3389\/fcell.2020.581045.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32415205\")'><img decoding=\"async\" width=\"75\" class=\"alignnone wp-image-1110\" alt=\"SciRep\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/SciRep-1-300x111.jpg\"><\/a><\/td>\n<td class=\"two\"><strong>Novotova M<\/strong>, <strong>Zahradnikova A Jr<\/strong>, Nichtova Z, Kovac R, Kralova E, Stankovicova T, <strong>Zahradnikova A<\/strong>, <strong>Zahradnik I<\/strong> (2020): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32415205\")'>Structural variability of dyads relates to calcium release in rat ventricular myocytes<\/a>. <i>Sci Rep<\/i> 10: 8076 doi: 10.1038\/s41598-020-64840-5.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32059483\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/cells-logo-1.png\"  width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Pires Da Silva J, Monceaux K, Guilbert A, Gressette M, Piquereau J, <strong>Novotova M<\/strong>, Ventura-Clapier R, Garnier A, Lemaire C (2020): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32059483\")'>SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K\/eEF2-Dependent Autophagy<\/a>. <i>Cells.<\/i> 9: E426 doi: 10.3390\/cells9020426.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30084984\")'><img decoding=\"async\" class=\"alignnone wp-image-1110\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/CardiovascRes.jpg\" alt=\"SciRep\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Prola A, <strong>Nichtova Z<\/strong>, Pires Da Silva J, Piquereau J, Monceaux K, Guilbert A, Gressette M, Ventura-Clapier R, Garnier A, <strong>Zahradnik I<\/strong>, <strong>Novotova M<\/strong>, Lemaire C (2019): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30084984\")'>Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes<\/a>. <i>Cardiovasc Res<\/i> 115: 328-342, doi: 10.1093\/cvr\/cvy197.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28239148\")'><img decoding=\"async\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/nat-com.jpg\" alt=\"PubMed\" align=\"middle\" border=\"0\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Ragni CV, Diguet N, Le Garrec JF, <strong>Novotova M<\/strong>, Resende TP, Pop S, Charon N, Guillemot L, Kitasato L, Badouel C, Dufour A, Olivo-Marin JC, Trouv\u00e9 A, McNeill H, Meilhac SM. (2017): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28239148\")'>Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.<\/a> <i>Nat Commun<\/i> 27: 14582.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28237688\")'><img decoding=\"async\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/Cellular_Signaling2.gif\" alt=\"PubMed\" align=\"middle\" border=\"0\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Misuth M, Joniova J, Horvath D, Dzurova L, <strong>Nichtova Z<\/strong>, <strong>Novotova M<\/strong>, Miskovsky P, Stroffekova K, Huntosova V. (2017): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28237688\")'>The flashlights on a distinct role of protein kinase C \u03b4: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells.<\/a> <i>Cell Signal<\/i> 34: 11\u201322.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28087315\")'><img decoding=\"async\" src=\"https:\/\/cdn.elsevier.com\/cover_img\/800.gif\" alt=\"PubMed\" align=\"middle\" border=\"0\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Huntosova V, <strong>Novotova M<\/strong>, <strong>Nichtova Z<\/strong>, Balogova L, Maslanakova M, Petrovajova D, Stroffekova K (2017): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28087315\")'>Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells.<\/a> <i>Toxicol In Vitro<\/i> 40: 184\u2013195.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27608616?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/GPB.jpg\" width=\"75\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\"><strong>Novotova M<\/strong>, <strong>Tarabova B<\/strong>, <strong>Tylkova L<\/strong>, Ventura-Clapier R, <strong>Zahradnik I<\/strong> (2016): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27608616?dopt=Citation\")'>Ultrastructural remodelling of slow skeletal muscle fibres in creatine kinase deficient mice: a quantitative study<\/a>. <i>Gen Physiol Biophys<\/i> 35: 477\u2013486.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Vplyv z\u00e1\u0165a\u017ee myokardu na distrib\u00faciu vn\u00fatorn\u00e9ho membr\u00e1nov\u00e9ho syst\u00e9mu srdcov\u00fdch myocytov &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Nasp\u00e4\u0165 Ved\u00faci projektu: Marta Novotov\u00e1 Trvanie: janu\u00e1r 2015 &#8211; december 2017 Koordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/vega-2-0110-15\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":117,"menu_order":105,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/387"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/comments?post=387"}],"version-history":[{"count":11,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/387\/revisions"}],"predecessor-version":[{"id":2562,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/387\/revisions\/2562"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/117"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/media?parent=387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}