{"id":384,"date":"2018-01-09T16:19:17","date_gmt":"2018-01-09T16:19:17","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/?page_id=384"},"modified":"2023-10-06T12:26:59","modified_gmt":"2023-10-06T12:26:59","slug":"apvv-sk-fr-2015-0007","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/apvv-sk-fr-2015-0007\/","title":{"rendered":"APVV-SK-FR-2015-0007"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>Vplyv stresu endoplazmatick\u00e9ho retikula na ultra\u0161trukt\u00faru a metabolizmus kardiomyocytov cicavcov  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Nasp\u00e4\u0165<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Ved\u00faci projektu: <a href=\"https:\/\/confolab.sav.sk\/ovsb\/pracovnici\/vyskumnici\/rndr-marta-novotova-csc\/\">Marta Novotov\u00e1<\/a><\/h3>\n<h3>Trvanie: janu\u00e1r 2016 &#8211; december 2017<br \/>\nKoordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej fyziol\u00f3gie a genetiky SAV, Bratislava<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Anot\u00e1cia:<\/span><\/h3>\n<p>Stres endoplazmatick\u00e9ho retikula (ER) sa podie\u013ea na mnoh\u00fdch kardiovaskul\u00e1rnych ochoreniach. V s\u00fa\u010dasnej dobe sa v\u00fdskum stresu ER zameriava na zachovanie skuto\u010dnej adapt\u00edvnej reakcie a na odstr\u00e1nenie zhubnej apopt\u00f3zy pri ochoreniach. Cie\u013eom tohto projektu je \u0161t\u00fadium adapta\u010dn\u00fdch zmien cytoarchitekt\u00fary kardiomyocytov s d\u00f4razom na obe formy retikul\u00e1rneho membr\u00e1nov\u00e9ho syst\u00e9mu &#8211; hladk\u00e9 a drsn\u00e9 retikulum &#8211; v podmienkach retikul\u00e1rneho stresu. Charakterizujeme remodelovanie cytoarchitekt\u00fary kardiomyocytov vyvolan\u00e9 aplik\u00e1ciou tunikamyc\u00ednu (retikul\u00e1rny stresor) v kontroln\u00fdch my\u0161iach a my\u0161iach s vyraden\u00fdm g\u00e9nom pre sirtuin1 (SIRT1 ciKO mice). Sirtuin1 je v\u0161eobecn\u00fd senzor metabolickej energie, ktor\u00fd sa aktivuje v d\u00f4sledku bunkov\u00e9ho stresu a chr\u00e1ni bunku pred apopt\u00f3zou. Predpoklad\u00e1me, \u017ee SIRT1 m\u00f4\u017ee regulova\u0165 tzv. &#8222;unfolded protein response&#8220; a chr\u00e1ni\u0165 srdce pred po\u0161koden\u00edm vyvolan\u00fdm stresom ER.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">K\u013e\u00fa\u010dov\u00e9 slov\u00e1:<\/span><\/h3>\n<p>Srdce, sval, retikul\u00e1rny stres, bunkov\u00e1 energetika, cytoarchitekt\u00fara, ultra\u0161trukt\u00fara, endoplazmatick\u00e9 retikulum<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Ciele:<\/span><\/h3>\n<p>Predkladan\u00fd projekt, ktor\u00fd nav\u00e4zuje na na\u0161u predch\u00e1dzaj\u00facu spolupr\u00e1cu, bude zameran\u00fd na \u010fal\u0161ie \u0161t\u00fadium dynamiky retikul\u00e1rneho membr\u00e1nov\u00e9ho syst\u00e9mu v srdcovom svale cicavcov v podmienkach retikul\u00e1rneho stresu. Projekt m\u00e1 dva aspekty: charakteriz\u00e1cia zmien indukovan\u00fdch stresom ER a \u0161t\u00fadium \u00falohy prote\u00ednu sirtuin1 (SIRT1) v modul\u00e1cii odpovede stresu ER v kardiomyocytoch. V prvom roku rie\u0161enia projektu sa zameriame na charakteriz\u00e1ciu morfol\u00f3gie retikul\u00e1rneho membr\u00e1nov\u00e9ho syst\u00e9mu kardiomyocytov papil\u00e1rneho svalu my\u0161\u00ed v podmienkach stresu endoplazmatick\u00e9ho retikula.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publik\u00e1cie:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32059483\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/cells-logo-1.png\"  width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Pires Da Silva J, Monceaux K, Guilbert A, Gressette M, Piquereau J, <strong>Novotova M<\/strong>, Ventura-Clapier R, Garnier A, Lemaire C (2020): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32059483\")'>SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K\/eEF2-Dependent Autophagy<\/a>. <i>Cells.<\/i> 9: E426 doi: 10.3390\/cells9020426.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30084984\")'><img decoding=\"async\" class=\"alignnone wp-image-1110\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/CardiovascRes.jpg\" alt=\"SciRep\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Prola A, <strong>Nichtova Z<\/strong>, Pires Da Silva J, Piquereau J, Monceaux K, Guilbert A, Gressette M, Ventura-Clapier R, Garnier A, <strong>Zahradnik I<\/strong>, <strong>Novotova M<\/strong>, Lemaire C (2019): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30084984\")'>Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes<\/a>. <i>Cardiovasc Res<\/i> 115: 328-342, doi: 10.1093\/cvr\/cvy197.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Vplyv stresu endoplazmatick\u00e9ho retikula na ultra\u0161trukt\u00faru a metabolizmus kardiomyocytov cicavcov &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Nasp\u00e4\u0165 Ved\u00faci projektu: Marta Novotov\u00e1 Trvanie: janu\u00e1r 2016 &#8211; december 2017 Koordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/apvv-sk-fr-2015-0007\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":117,"menu_order":100,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/384"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/comments?post=384"}],"version-history":[{"count":7,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/384\/revisions"}],"predecessor-version":[{"id":2557,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/384\/revisions\/2557"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/117"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/media?parent=384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}