{"id":350,"date":"2018-01-09T15:15:09","date_gmt":"2018-01-09T15:15:09","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/?page_id=350"},"modified":"2023-10-06T12:21:52","modified_gmt":"2023-10-06T12:21:52","slug":"apvv-15-0302","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/apvv-15-0302\/","title":{"rendered":"APVV-15-0302"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>Cytoarchitekt\u00fara v\u00e1pnikovej signaliz\u00e1cie srdcov\u00fdch myocytov vo v\u00fdvoji hypertrofie myokardu (CAMYS) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Nasp\u00e4\u0165<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Ved\u00faci projektu: <a href=\"https:\/\/confolab.sav.sk\/ovsb\/pracovnici\/vyskumnici\/ing-alexandra-zahradnikova-drsc\/\">Alexandra Zahradn\u00edkov\u00e1<\/a><\/h3>\n<h3>Trvanie: j\u00fal 2016 &#8211; j\u00fan 2019<br \/>\nKoordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej fyziol\u00f3gie a genetiky SAV, Bratislava (2016-2017), \u00dastav experiment\u00e1lnej endokrinol\u00f3gie BMC SAV, Bratislava (2018-2019)<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Anot\u00e1cia:<\/span><\/h3>\n<p>V ran\u00fdch f\u00e1zach v\u00fdvoja mnoh\u00fdch kardiovaskul\u00e1rnych ochoren\u00ed doch\u00e1dza k oslabeniu v\u00e1pnikovej signaliz\u00e1cie a k aktiv\u00e1cii hypertrofie kardiomyocytov. V\u00e1pnikov\u00e1 signaliz\u00e1cia okrem riadenia kontraktilnej funkcie moduluje mno\u017estvo signaliza\u010dn\u00fdch dr\u00e1h a metabolizmus myocytov. Preto jej naru\u0161enie, \u010di u\u017e po\u010das systoly alebo diastoly, m\u00f4\u017ee by\u0165 nielen d\u00f4sledkom, ale aj pr\u00ed\u010dinou maladapta\u010dnej reakcie myocytov na pre\u0165a\u017eenie. Predpoklad\u00e1me, \u017ee procesy spojen\u00e9 s hypertrofiou ved\u00fa k zmen\u00e1m v distrib\u00facii zlo\u017eiek syst\u00e9mu endo\/sarkoplazmatick\u00e9ho retikula zabezpe\u010duj\u00facich tvorbu a \u0161\u00edrenie v\u00e1pnikov\u00fdch sign\u00e1lov a s nimi s\u00favisiacu zmenu expresie a distrib\u00facie prote\u00ednov. Cie\u013eom projektu je zisti\u0165 rozdiely v syst\u00e9me v\u00e1pnikovej signaliz\u00e1cie kardiomyocytov myokardu adaptuj\u00faceho sa na patologick\u00fa a fyziologick\u00fa z\u00e1\u0165a\u017e a porovna\u0165 ich s v\u00fdvojom syst\u00e9mu v\u00e1pnikovej signaliz\u00e1cie kardiomyocytov po\u010das postnat\u00e1lneho rozvoja myokardu. Stav syst\u00e9mu v\u00e1pnikovej signaliz\u00e1cie budeme analyzova\u0165 v modeloch z\u00e1\u0165a\u017ee myokardu laborat\u00f3rneho potkana: a\/ sedent\u00e1rny model &#8211; \u0161tandardn\u00fd klietkov\u00fd chov,  b\/ model fyziologickej z\u00e1\u0165a\u017ee &#8211; chov v klietkach s behac\u00edm kolesom, c\/ model tlakov\u00e9ho za\u0165a\u017eenia &#8211; opera\u010dn\u00e1 ob\u0161trukcia vzostupnej aorty, a d\/ rastov\u00fd model hypertrofie &#8211; postnat\u00e1lny v\u00fdvoj myokardu. Pou\u017eijeme modern\u00e9 met\u00f3dy elektrofyziol\u00f3gie, molekul\u00e1rnej biol\u00f3gie a ultra\u0161trukt\u00farnej mikroskopie pre charakteriz\u00e1ciu kvality a distrib\u00facie v\u00e1pnikov\u00fdch sign\u00e1lov, rozsahu a distrib\u00facie hladk\u00e9ho a ribozom\u00e1lneho endoplazmatick\u00e9ho retikula, a expresie, lokaliz\u00e1cie a kolokaliz\u00e1cie prote\u00ednov v\u00e1pnikovej signaliz\u00e1cie. O\u010dak\u00e1vame, \u017ee multidisciplin\u00e1rny pr\u00edstup podlo\u017een\u00fd expert\u00edzou kolekt\u00edvu rie\u0161ite\u013eov n\u00e1m umo\u017en\u00ed interpretova\u0165 bunkov\u00e9 a molekulov\u00e9 mechanizmy v\u00e1pnikovej signaliz\u00e1cie a vyvodi\u0165 z\u00e1very relevantn\u00e9 pre pochopenie mechanizmov srdcov\u00e9ho zlyhania, ktor\u00e9 umo\u017enia v\u00fdvoj nov\u00fdch lie\u010debn\u00fdch a prevent\u00edvnych postupov.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">K\u013e\u00fa\u010dov\u00e9 slov\u00e1:<\/span><\/h3>\n<p>myokard, hypertrofia, postnat\u00e1lny v\u00fdvoj, fyziologick\u00e1 z\u00e1\u0165a\u017e, tlakov\u00e9 pre\u0165a\u017eenie, kardiomyocyt, v\u00e1pnikov\u00e1 signaliz\u00e1cia,  cytoarchitekt\u00fara, retikularny membranovy syst\u00e9m, expresia prote\u00ednov, kolokaliz\u00e1cia prote\u00ednov<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Ciele:<\/span><\/h3>\n<p>Cie\u013eom projektu je objasni\u0165 \u00falohu molekulov\u00fdch a bunkov\u00fdch faktorov diastolickej a systolickej v\u00e1pnikovej signaliz\u00e1cie po\u010das v\u00fdvoja a v skor\u00fdch \u0161t\u00e1di\u00e1ch adapt\u00e1cie kardiomyocytov na stresov\u00e9 stimuly ved\u00face k hypertrofii myokardu. Cie\u013e dosiahneme sledovan\u00edm lok\u00e1lneho uvo\u013e\u0148ovania v\u00e1pnika prostredn\u00edctvom spont\u00e1nnych a evokovan\u00fdch v\u00e1pnikov\u00fdch z\u00e1bleskov, sledovan\u00edm expresie a lokaliz\u00e1cie RyR2 a IP3R2 kan\u00e1lov a markerov membr\u00e1nov\u00fdch kompartmentov a sledovan\u00edm mikroarchitekt\u00fary myocytov na experiment\u00e1lnych modeloch fyziologickej a patologickej hypertrofie myokardu.<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">V\u00fdsledky:<\/span><\/h3>\n<p>Projekt bol zameran\u00fd na \u0161t\u00fadium v\u00e1pnikovej signaliz\u00e1cie a relevantnej mikroarchitekt\u00fary myocytov po\u010das adapt\u00e1cie myokardu na fyziologick\u00fa a patofyziologick\u00fa z\u00e1\u0165a\u017e. <\/p>\n<p>Identifikovali a charakterizovali sme hlavn\u00e9 molekulov\u00e9 a bunkov\u00e9 faktory ur\u010duj\u00face funkciu syst\u00e9mu v\u00e1pnikovej signaliz\u00e1cie srdcov\u00fdch myocytov v ranej f\u00e1ze rozvoja zlyhania myokardu a preuk\u00e1zali ich spolu\u00fa\u010das\u0165 na remodelovan\u00ed myokardu. Charakterizovali sme zmeny ultra\u0161trukt\u00fary a v\u00e1pnikovej signaliz\u00e1cie v dvoch modeloch fyziologickej bunkovej hypertrofie a v ran\u00fdch \u0161t\u00e1di\u00e1ch dvoch patologick\u00fdch modelov. Uk\u00e1zali sme, \u017ee fyziologick\u00e9 a patologick\u00e9 modely sa odli\u0161uj\u00fa charakterom zmien v kinetike v\u00e1pnikovej signaliz\u00e1cie: zatia\u013e \u010do u fyziologickej bunkovej hypertrofie doch\u00e1dza k zr\u00fdchleniu v\u00e1pnikovej signaliz\u00e1cie, v ran\u00fdch patologick\u00fdch stavoch sa v\u00e1pnikov\u00e1 signaliz\u00e1cia spoma\u013euje. Ultra\u0161trukt\u00farne a molekulov\u00e9 zmeny u jednotliv\u00fdch modelov sa navz\u00e1jom l\u00ed\u0161ia, pri\u010dom hlavn\u00fdmi pozorovan\u00fdmi zmenami \u010di u\u017e vo fyziologick\u00fdch, alebo patologick\u00fdch modeloch boli zmeny v objemovej hustote di\u00e1d, \u0161trukt\u00fare di\u00e1d, expresii membr\u00e1nov\u00fdch prote\u00ednov, a v charaktere a objemovej hustote mitochondri\u00ed. <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publik\u00e1cie:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34535195\/\")'><img decoding=\"async\" loading=\"lazy\" width=\"75\" height=\"20\" class=\"alignnone\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/BiolSexDiffer.png\"><\/a><\/td>\n<td class=\"two\">Grimbert L, Sanz MN, Gressette M, Rucker-Martin C, <strong>Novotova M<\/strong>, Solgadi A, Karoui A, Gomez S, Bedouet K, Jacquet E, Lemaire C, Veksler V, Mericskay M, Ventura-Clapier R, Piquereau JM, Garnier A (2021): <a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34535195\/\")'>Spatiotemporal AMPK alpha 2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only<\/a>. <i>Biol Sex Differ<\/i>, vol 12: 52. doi: 10.1186\/s13293-021-00394-z.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34118053\/\")'><img decoding=\"async\" loading=\"lazy\" width=\"75\" height=\"104\" class=\"alignnone\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/Mitochondrial_Medicine.jpg\"><\/a><\/td>\n<td class=\"two\">Marcek Chorvatova A, <strong>Cagalinec M<\/strong>, Chorvat D Jr (2021): <a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34118053\/\")'>Time-resolved imaging of mitochondrial flavin fluorescence and its applications for evaluating the oxidative state in living cardiac cells<\/a>. <i>Mitochondrial Medicine. Methods in Molecular Biology<\/i>, vol 2275, chapter 26: 403-414. Humana, New York, NY. Volume 1: Targeting Mitochondria, Weissig V., Edeas M. (eds), ISBN 978-1-0716-1262-0, doi: 10.1007\/978-1-0716-1262-0_26.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\" width=\"5%\"><a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33735373\/\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1114\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/m_jgp_2021_153_4.cover_.png\" alt=\"JGP\" width=\"80\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\"><strong>Iaparov B<\/strong>, <strong>Zahradnik I<\/strong>, Moskvin AS, <strong>Zahradnikova A<\/strong> (2021): <a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33735373\/\")'>In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes<\/a>. <i>J Gen Physiol<\/i> 153: e202012685 doi: 10.1085\/jgp.202012685.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33084603\/\")'><img decoding=\"async\" loading=\"lazy\" width=\"75\" height=\"104\" class=\"alignnone\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/GPB-1.jpg\"><\/a><\/td>\n<td class=\"two\">Kurekova S, Plaas M, <strong>Cagalinec M<\/strong> (2020): <a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33084603\/\")'>Short Communication: Lack of functional wolframin causes drop in  plasmalemmal sodium-calcium exchanger type  1 expression at  early stage in  rat model of  Wolfram syndrome<\/a>. <i>Gen Physiol Biophys<\/i> 39: 499\u2013503 doi: 10.4149\/gpb_2020017.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.08.26.260968v1\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/bioRxiv_article.jpg\" alt=\"Prog Biophys Mol Biol\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"> <strong>Iaparov B<\/strong>, <strong>Zahradnik I<\/strong>, Moskvin AS, <strong>Zahradnikova A<\/strong> (2020): <a href='javascript:launchRemote(\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.08.26.260968v1\")'>Synergy of calcium release site determinants in control of calcium release events in cardiac myocytes<\/a>. <i>bioRXiv<\/i> :  doi: https:\/\/doi.org\/10.1101\/2020.08.26.260968.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32416189\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/ProgBiophysMolBiol-e1590139461171.jpg\" alt=\"Prog Biophys Mol Biol\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Iaparov B<\/strong>, <strong>Zahradnik I<\/strong> (2020): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32416189\")'>The problem of accuracy in single-channel open probability measurements<\/a>. <i>Prog Biophys Mol Biol<\/i> 157: 94-106 doi: 10.1016\/j.pbiomolbio.2020.05.002.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32415205\")'><img decoding=\"async\" width=\"75\" class=\"alignnone wp-image-1110\" alt=\"SciRep\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/SciRep-1-300x111.jpg\"><\/a><\/td>\n<td class=\"two\"><strong>Novotova M<\/strong>, <strong>Zahradnikova A Jr<\/strong>, Nichtova Z, Kovac R, Kralova E, Stankovicova T, <strong>Zahradnikova A<\/strong>, <strong>Zahradnik I<\/strong> (2020): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32415205\")'>Structural variability of dyads relates to calcium release in rat ventricular myocytes<\/a>. <i>Sci Rep<\/i> 10: 8076 doi: 10.1038\/s41598-020-64840-5.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32059483\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/cells-logo-1.png\"  width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Pires Da Silva J, Monceaux K, Guilbert A, Gressette M, Piquereau J, <strong>Novotova M<\/strong>, Ventura-Clapier R, Garnier A, Lemaire C (2020): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32059483\")'>SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K\/eEF2-Dependent Autophagy<\/a>. <i>Cells.<\/i> 9: E426 doi: 10.3390\/cells9020426.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31236612\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/EurBiophysJ.jpg\" alt=\"Eur Biophys J\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Iaparov B, Moskvin AS, <strong>Zahradnik I<\/strong>, <strong>Zahradnikova A<\/strong> (2019): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31236612\")'>Stochastic and deterministic approaches to modelling calcium release in cardiac myocytes at different spatial arrangements of ryanodine receptors<\/a>. <i>Eur Biophys J<\/i> 48: 579\u2013584 doi: 10.1007\/s00249-019-01378-z.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31145728\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1110\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/PLoSOne.jpg\" alt=\"PLoSOne\" width=\"75\" height=\"54\" \/><\/a><\/td>\n<td class=\"two\">Skrabanek P, <strong>Zahradnikova A Jr<\/strong> (2019): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31145728\")'>Automatic assessment of the cardiomyocyte development stages from confocal microscopy images using deep convolutional networks<\/a>. <i>PLoS One<\/i> 14: e0216720, doi: 10.1371\/journal.pone.0216720.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30930784\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontiersPhysiol-150x51.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" height=\"17\" \/><\/a><\/td>\n<td class=\"two\"><strong>Cagalinec M<\/strong>, <strong>Zahradnikova A<\/strong>, <strong>Zahradnikova A Jr<\/strong>, Kovacova D, Paulis L, <strong>Kurekova S<\/strong>, <strong>Hotka M<\/strong>, <strong>Pavelkova J<\/strong>, Plaas M, <strong>Novotova M<\/strong>, <strong>Zahradnik I<\/strong> (2019). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30930784\")'>Calcium signaling and contractility in cardiac myocyte of wolframin deficient rats<\/a>. <i>Front Physiol<\/i> 10: 172, doi: 10.3389\/fphys.2019.00172.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30084984\")'><img decoding=\"async\" class=\"alignnone wp-image-1110\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/CardiovascRes.jpg\" alt=\"SciRep\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Prola A, <strong>Nichtova Z<\/strong>, Pires Da Silva J, Piquereau J, Monceaux K, Guilbert A, Gressette M, Ventura-Clapier R, Garnier A, <strong>Zahradnik I<\/strong>, <strong>Novotova M<\/strong>, Lemaire C (2019): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30084984\")'>Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes<\/a>. <i>Cardiovasc Res<\/i> 115: 328-342, doi: 10.1093\/cvr\/cvy197.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23741324\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1110\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/PLoSOne.jpg\" alt=\"PLoSOne\" width=\"75\" height=\"54\" \/><\/a><\/td>\n<td class=\"two\"><strong>Hotka M<\/strong>, <strong>Zahradnik I<\/strong> (2017): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29166646\")'>Reconstruction of membrane current by deconvolution and its application to membrane capacitance measurements in cardiac myocytes<\/a>. <i>PLoS One<\/i> 12: e0188452.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28913625\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/EurBiophysJ.jpg\" alt=\"Eur Biophys J\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"><strong>Mackova K<\/strong>, <strong>Zahradnikova A Jr<\/strong>, <strong>Hotka M<\/strong>, <strong>Hoffmannova B<\/strong>, <strong>Zahradnik I<\/strong>, <strong>Zahradnikova A<\/strong> (2017). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28913625\")'>Calcium release-dependent inactivation precedes formation of the tubular system in developing rat cardiac myocytes<\/a>. <i>Eur Biophys J<\/i> 46: 691-703.<br \/>\n<a href='javascript:launchRemote(\"https:\/\/rdcu.be\/ytHi\")'><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/SharedIt.jpg\" alt=\"SharedIt\" width=\"45\" height=\"20\" class=\"alignnone size-full wp-image-2021\" \/><\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28713282\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontiersPhysiol-150x51.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" height=\"17\" \/><\/a><\/td>\n<td class=\"two\"><strong>Faltinova A<\/strong>, Tomaskova N, Antalik M, Sevcik J, <strong>Zahradnikova A<\/strong> (2017). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28713282\")'>The N-terminal region of the ryanodine receptor affects channel activation<\/a>. <i>Front Physiol<\/i> 8: 443.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28237688\")'><img decoding=\"async\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/Cellular_Signaling2.gif\" alt=\"PubMed\" align=\"middle\" border=\"0\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Misuth M, Joniova J, Horvath D, Dzurova L, <strong>Nichtova Z<\/strong>, <strong>Novotova M<\/strong>, Miskovsky P, Stroffekova K, Huntosova V. (2017): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28237688\")'>The flashlights on a distinct role of protein kinase C \u03b4: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells.<\/a> <i>Cell Signal<\/i> 34: 11\u201322.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28087315\")'><img decoding=\"async\" src=\"https:\/\/cdn.elsevier.com\/cover_img\/800.gif\" alt=\"PubMed\" align=\"middle\" border=\"0\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Huntosova V, <strong>Novotova M<\/strong>, <strong>Nichtova Z<\/strong>, Balogova L, Maslanakova M, Petrovajova D, Stroffekova K (2017): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28087315\")'>Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells.<\/a> <i>Toxicol In Vitro<\/i> 40: 184\u2013195.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22781817\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/GPB.jpg\" width=\"75\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\"><strong>Novotova M<\/strong>, <strong>Tarabova B<\/strong>, <strong>Tylkova L<\/strong>, Ventura-Clapier R, <strong>Zahradnik I<\/strong> (2016): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27608616?dopt=Citation\")'>Ultrastructural remodelling of slow skeletal muscle fibres in creatine kinase deficient mice: a quantitative study<\/a>. <i>Gen Physiol Biophys<\/i> 35: 477\u2013486.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Cytoarchitekt\u00fara v\u00e1pnikovej signaliz\u00e1cie srdcov\u00fdch myocytov vo v\u00fdvoji hypertrofie myokardu (CAMYS) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Nasp\u00e4\u0165 Ved\u00faci projektu: Alexandra Zahradn\u00edkov\u00e1 Trvanie: j\u00fal 2016 &#8211; j\u00fan 2019 Koordinuj\u00faca organiz\u00e1cia: \u00dastav molekul\u00e1rnej&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/projekty\/ukoncene-projekty\/apvv-15-0302\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":117,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/350"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/comments?post=350"}],"version-history":[{"count":31,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/350\/revisions"}],"predecessor-version":[{"id":2556,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/350\/revisions\/2556"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/117"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/media?parent=350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}