{"id":1316,"date":"2020-03-30T10:58:38","date_gmt":"2020-03-30T10:58:38","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/?page_id=1316"},"modified":"2023-10-05T14:58:30","modified_gmt":"2023-10-05T14:58:30","slug":"era-cvd_jtc2019-055","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/projekty\/aktivne-projekty\/era-cvd_jtc2019-055\/","title":{"rendered":"ERA-CVD_JTC2019-055"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>HF-MetaB &#8211; Metabolick\u00e1 terapia srdcov\u00e9ho zlyhania: \u00faloha vitam\u00ednov B &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Nasp\u00e4\u0165<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Ved\u00faci projektu: <a href=\"https:\/\/confolab.sav.sk\/ovsb\/pracovnici\/vyskumnici\/rndr-alexandra-zahradnikova-ml-phd\/\">Alexandra Zahradn\u00edkov\u00e1 ml.<\/a><\/h3>\n<h3>Trvanie: apr\u00edl 2020 \u2013 marec 2024<br \/>\nKoordinuj\u00faca organiz\u00e1cia: INSERM, Paris Sud University, Laboratory of signalling and cardiovascular pathophysiology<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Anot\u00e1cia:<\/span><\/h3>\n<p>Zlyh\u00e1vanie srdca (ZS) je celosvetovo v\u00fdznamnou pr\u00ed\u010dinou smrti. Je zrejm\u00e9, \u017ee s\u00fa\u010das\u0165ou v\u00fdvinu ZS s\u00fa markantn\u00e9 zmeny energetick\u00e9ho metabolizmu. Tieto, okrem in\u00e9ho, zah\u0155\u0148aj\u00fa pokles hladiny nosi\u010dov energie \u2013 ATP, fosfokreat\u00ednu a nikot\u00ednamid aden\u00edn dinukleotidu (NAD+), d\u00f4le\u017eit\u00e9ho koenz\u00fdmu v glykol\u00fdze a mitochondri\u00e1lnej synt\u00e9ze ATP. V predch\u00e1dzaj\u00facej \u0161t\u00fadii sme v my\u0161acom modeli tlakov\u00e9ho pre\u0165a\u017eenia srdca uk\u00e1zali protekt\u00edvny \u00fa\u010dinok doplnenia v\u00fd\u017eivy o dva vitam\u00edny (B12\/B9), ktor\u00e9 stimuluj\u00fa mitochondri\u00e1lnu biogen\u00e9zu alebo nikot\u00ednamid ribozid (NR), ned\u00e1vno charakterizovan\u00fdm vitam\u00ednom B3, ktor\u00fd je prekurzorom NAD+. Ke\u010f\u017ee tieto doplnky boli v na\u0161ej \u0161t\u00fadii pod\u00e1van\u00e9 pred n\u00e1stupom prv\u00fdch sympt\u00f3mov ZS, tu navrhujeme testova\u0165 efektivitu pod\u00e1vania koktailu t\u00fdchto troch vitam\u00ednov B po\u010das symptomatick\u00e9ho ZS u my\u0161\u00ed s cie\u013eom navrhn\u00fa\u0165 pr\u00edpadn\u00e9 pou\u017eitie v lie\u010dbe. Na\u0161im prim\u00e1rnym cie\u013eom bude zisti\u0165 \u00fa\u010dinok koktailu na pre\u017e\u00edvanie, funk\u010dn\u00fa kapacitu, funkciu srdca, mitochondri\u00e1lnu respir\u00e1ciu a dynamiku, metabolizmus v\u00e1pnika a metabolick\u00e9 fluxy. V perspekt\u00edve transl\u00e1cie do kliniky tie\u017e zhodnot\u00edme vplyv tohto koktailu v kontexte \u0161tandardnej lie\u010dby ZS (\u03b2-blok\u00e1tory, ACE inhib\u00edtory). Je tie\u017e kriticky d\u00f4le\u017eit\u00e9 zoh\u013eadni\u0165 pohlavn\u00e9 rozdiely v lie\u010dbe ZS. Preto druh\u00fdm cie\u013eom tohto projektu je porovna\u0165 efekt lie\u010dby u samcov a sam\u00edc, ktor\u00e9 sa l\u00ed\u0161ia v zmen\u00e1ch mitochondri\u00e1lneho a v\u00e1pnikov\u00e9ho metabolizmu po\u010das ZS.\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">K\u013e\u00fa\u010dov\u00e9 slov\u00e1:<\/span><\/h3>\n<p>zlyh\u00e1vanie srdca, energetick\u00fd metabolizmus, mitochondrie, v\u00e1pnikov\u00e1 signaliz\u00e1cia, metabolick\u00e1 terapia, B vitam\u00edny <\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Ciele:<\/span><\/h3>\n<p>Cie\u013eom projektu je zisti\u0165 efekt metabolickej terapie u my\u0161\u00ed s klinick\u00fdmi prejavmi zlyh\u00e1vania srdca:<\/p>\n<ul>\n<li> \u00da\u010dinok samotnej metabolickej terapie na pre\u017e\u00edvanie, funk\u010dn\u00fa kapacitu, funkciu srdca a stav mitochondri\u00ed. <\/li>\n<li> \u00da\u010dinok metabolickej terapie s\u00fa\u010dasne s be\u017enou lie\u010dbu ZS (\u03b2-blok\u00e1tory, ACE inhib\u00edtory). <\/li>\n<li> Rozdiely v \u00fa\u010dinku medzi pohlaviami. <\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publik\u00e1cie:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36609141\/\")'><img decoding=\"async\" class=\"alignnone wp-image-1111\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/BiophysJnew.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"><strong>Baglaeva I<\/strong>, <strong>Iaparov B<\/strong>, <strong>Zahradnik I<\/strong>, <strong>Zahradnikova A<\/strong> (2023). <a href='javascript:launchRemote(\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36609141\/\")'>Analysis of noisy transient signals based on Gaussian process regression<\/a>. <i>Biophys J<\/i> 122: 451\u2013459. doi: 10.1016\/j.bpj.2023.01.003.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>HF-MetaB &#8211; Metabolick\u00e1 terapia srdcov\u00e9ho zlyhania: \u00faloha vitam\u00ednov B &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Nasp\u00e4\u0165 Ved\u00faci projektu: Alexandra Zahradn\u00edkov\u00e1 ml. Trvanie: apr\u00edl 2020 \u2013 marec 2024 Koordinuj\u00faca organiz\u00e1cia: INSERM, Paris&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/projekty\/aktivne-projekty\/era-cvd_jtc2019-055\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":116,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/1316"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/comments?post=1316"}],"version-history":[{"count":12,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/1316\/revisions"}],"predecessor-version":[{"id":2544,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/1316\/revisions\/2544"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/pages\/116"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/wp-json\/wp\/v2\/media?parent=1316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}