{"id":406,"date":"2018-01-10T13:47:27","date_gmt":"2018-01-10T12:47:27","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/en\/?page_id=406"},"modified":"2024-02-16T13:55:55","modified_gmt":"2024-02-16T12:55:55","slug":"hhmi-75195547801","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/completed-projects\/hhmi-75195547801\/","title":{"rendered":"HHMI-75195547801"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>Ryanodine receptor and excitation-contraction coupling&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Back<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Principal Investigator: <a href=\"http:\/\/www.umfg.sav.sk\/ovsb\/en\/people\/researchers\/zahradnikova-a\/\">Alexandra Zahradn\u00edkov\u00e1<\/a><\/h3>\n<h3>Duration: April 1995 &#8211; August 2000<br \/>\nCoordinating Organization: Institute of Molecular Physiology and Genetics SAS, Bratislava<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Annotation:<\/span><\/h3>\n<p>The cardiac ryanodine receptor (RyR) is a membrane protein located in the junctional sarcoplasmic reticulum (jSR), where it functions as a calcium release channel. The jSR is in close apposition to the membrane of t-tubules containing the L-type calcium channel (DHPR), which triggers calcium release from the SR when the influx of Ca2+ ions through the DHPR following membrane depolarization activates nearby RyRs (calcium-induced calcium release, CICR). We propose that the global conformational changes of the RyR (gating modes) play an important role in the response of the RyR to both, brief and sustained stimuli.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Keywords:<\/span><\/h3>\n<p>ryanodine receptor, modal gating, mathematical models, planar lipid bilayers<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Objectives:<\/span><\/h3>\n<p>The aim of the project is to elucidate the mechanism of modal transition of the RyR channel and to determine their impact on the gradation and termination of calcium-induced calcium release, using a combination of experimental and theoretical approaches.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publications:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14535832?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1120\" src=\"https:\/\/www.biomed.cas.cz\/physiolres\/img\/S5_2015.jpg\" alt=\"AJPCell\" width=\"75\" height=\"100\" \/><\/a><\/td>\n<td class=\"two\"><strong>Dura M<\/strong>, <strong>Zahradnik I<\/strong>, <strong>Zahradnikova A<\/strong> (2003): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14535832?dopt=Citation\")'>Kinetics of cardiac RyR channel gating studied at high temporal resolution.<\/a><i> Physiol Res.<\/i> 52: 571-578.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10398857?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1120\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/Pflugers-1.jpg\" alt=\"AJPCell\" width=\"75\" height=\"100\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Dura M<\/strong>, Gyorke S (1999): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10398857?dopt=Citation\")'>Modal gating transitions in cardiac ryanodine receptors during increases of Ca2+ concentration produced by photolysis of caged Ca2+.<\/a><i> Pflugers Arch.<\/i> 438: 283-288.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10320679?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1113\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0005273606X07319-cov150h.gif\" alt=\"JPhysiol3\" width=\"75\" height=\"95\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Zahradnik I<\/strong> (1999): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10320679?dopt=Citation\")'>Analysis of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles using models derived from single-channel data.<\/a><i> Biochimica Et Biophys Acta-Biomembr.<\/i> 1418: 268-284.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10578015?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1114\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JGP-125x150.jpg\" alt=\"JGP\" width=\"75\" height=\"98\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Zahradnik I<\/strong>, Gyorke I, Gyorke S (1999). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10578015?dopt=Citation\")'>Rapid activation of the cardiac ryanodine receptor by submillisecond calcium stimuli.<\/a><i> J Gen Physiol.<\/i> 114: 787-798.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9570009?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1114\" src=\"https:\/\/cdn.elsevier.com\/cover_img\/623014.gif\" alt=\"JGP\" width=\"75\" height=\"98\" \/><\/a><\/td>\n<td class=\"two\">Meszaros L G, <strong>Zahradnikova A<\/strong>, Volpe P (1998): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9570009?dopt=Citation\")'>Kinetic basis of quantal calcium release from intracellular calcium stoves.<\/a><i> Cell Calcium.<\/i> 23: 43-52.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9547378?dopt=Citation\")'><img decoding=\"async\" class=\"alignnone wp-image-1113\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JPhysiol3.jpg\" alt=\"JPhysiol3\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, Meszaros L G (1998). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9547378?dopt=Citation\")'>Voltage change-induced gating transitions of the rabbit skeletal muscle Ca2+ release channel.<\/a><i> J. Physiol.<\/i> 509: 29-38.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9502194?dopt=Citation\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1114\" src=\"https:\/\/cdn.elsevier.com\/cover_img\/623014.gif\" alt=\"JGP\" width=\"75\" height=\"98\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Minarovic I<\/strong>, Venema R C,  Meszaros L G (1997): <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9502194?dopt=Citation\")'>Inactivation of the cardiac ryanodine receptor calcium release channel by nitric oxide.<\/a><i> Cell Calcium.<\/i> 22: 447-453.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8968571\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1123\" src=\"https:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/BiophysJ-150x150.jpg\" alt=\"BiophysJ\" width=\"75\" height=\"100\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>,<strong> Zahradnik I<\/strong> (1996). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8968571\")'>A minimal gating model for the cardiac calcium release channel.<\/a> <i>Biophys J.<\/i> 71: 2996-3012.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Ryanodine receptor and excitation-contraction coupling&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Back Principal Investigator: Alexandra Zahradn\u00edkov\u00e1 Duration: April 1995 &#8211; August 2000 Coordinating Organization: Institute of Molecular Physiology and Genetics SAS, Bratislava&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/completed-projects\/hhmi-75195547801\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":199,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/406"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/comments?post=406"}],"version-history":[{"count":3,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/406\/revisions"}],"predecessor-version":[{"id":1627,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/406\/revisions\/1627"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/199"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/media?parent=406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}