{"id":384,"date":"2018-01-10T10:12:48","date_gmt":"2018-01-10T09:12:48","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/en\/?page_id=384"},"modified":"2024-02-16T13:39:05","modified_gmt":"2024-02-16T12:39:05","slug":"vega-2-0116-12","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/completed-projects\/vega-2-0116-12\/","title":{"rendered":"VEGA 2\/0116\/12"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>Plasticity of the membrane systems of cardiac myocytes&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Back<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Principal Investigator: <a href=\"http:\/\/www.umfg.sav.sk\/ovsb\/en\/people\/researchers\/novotova-m\/\">Marta Novotov\u00e1<\/a><\/h3>\n<h3>Duration: January 2012 &#8211; December 2014<br \/>\nCoordinating Organization: Institute of Molecular Physiology and Genetics SAS, Bratislava<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Annotation:<\/span><\/h3>\n<p>In our previous studies, we have shown that cytoarchitecture contributes to intracellular signaling in cardiac myocytes and that cytoarchitectual changes accompany cardiac remodeling. This project aims at characterization of the morphological variability of the sarcolemma and of the sarcoplasmic reticulum with emphasis on the local aspects of excitation-contraction coupling. Changes in the spatial relations of the plasma membrane and of membranes of the sarcoplasmic reticulum will be studied in the mammalian myocardium with the aim to classify and quantify their structural dynamics in the physiologically and pathologically loaded myocardium. Comprehension of the plasticity of the membrane system will be instrumental in understanding of the membrane morphology as the adaptability factor in cardiac myocytes.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Keywords:<\/span><\/h3>\n<p>Cardiac workload, cardiac myocytes, cytoarchitecture, remodelling<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Objectives:<\/span><\/h3>\n<p>The project is aimed to collect basic knowledge on the membrane plasticity and the ultrastructural dynamics of the membrane systems in mammalian cardiac muscle cells working under normal and pathological conditions. The expected results will help to reveal how the morphology of the cell membrane participates on signaling processes and which structural mechanisms participate in remodeling of the membrane system during adaptation to changes in load.<br \/>\nWe will characterize the morphological plasticity of the plasma membrane, its tubular system, of the sarcoplasmic reticulum and its terminal cisterns with emphasis on changes in dyadic microdomains of myocytes of left ventricles and papillary muscles of experimental animals exposed to:<\/p>\n<ul>\n<li>physiological work load<\/li>\n<li>experimentally induced myocardial damage<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publications:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25371090\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1138\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/Metallomics-150x150.jpg\" alt=\"Metallomics\" width=\"75\" height=\"100\" \/><\/a><\/td>\n<td class=\"two\">Huntosova V, Stroffekova K, Wagnieres G, <strong>Novotova M<\/strong>, <strong>Nichtova Z<\/strong>, Miskovsky P (2014): <a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25371090\")'>Endosomes: guardians against [Ru(Phen)] photo-action in endothelial cells during in vivo pO2 detection?<\/a> <i>Metallomics<\/i> 6: 2279-2289.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24042504\")'><img decoding=\"async\" class=\"alignnone wp-image-1113\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/JPhysiol3.jpg\" alt=\"JPhysiol3\" width=\"75\" \/><\/a><\/td>\n<td class=\"two\">Caffin F, Prola A, Piquereau J, <strong>Novotova M<\/strong>, David DJ, Garnier A, Fortin D, Alavi M, Veksler V, Ventura-Clapier R, Joubert F (2013): <a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24042504\")'>Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice<\/a>. <i>J Physiol<\/i> 591: 6017-37.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23903554\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1142\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/5-150x150.jpg\" alt=\"5\" width=\"75\" height=\"101\" \/><\/a><\/td>\n<td class=\"two\"><strong>Misak A<\/strong>, <strong>Grman M<\/strong>, <strong>Malekova L<\/strong>, <strong>Novotova M<\/strong>, <strong>Markova J<\/strong>, <strong>Krizanova O<\/strong>, <strong>Ondrias K<\/strong>, <strong>Tomaskova Z<\/strong> (2013): <a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23903554\")'>Mitochondrial chloride channels: electrophysiological characterization and pH induction of channel pore dilation<\/a>. <i>Eur Biophys J<\/i> 42: 709-20.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23675354\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1111\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontiersPhysiol-150x51.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" height=\"17\" \/><\/a><\/td>\n<td class=\"two\">Piquereau J, Caffin F, <strong>Novotova M<\/strong>, Lemaire C, Veksler V, Garnier A, Ventura-Clapier R, Joubert F (2013): <a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23675354\")'>Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?<\/a> <i>Front Physiol<\/i> 4: 102.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22934071\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1111\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontiersPhysiol-150x51.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" height=\"17\" \/><\/a><\/td>\n<td class=\"two\"><strong>Zahradnikova A<\/strong>, <strong>Zahradnik I<\/strong> (2012). <a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22934071\")'>Construction of calcium release sites in cardiac myocytes<\/a>. <i>Front Physiol<\/i> 3: 322.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22406748\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1115\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/CardiovascRes-150x150.jpg\" alt=\"CardiovascRes\" width=\"75\" height=\"105\" \/><\/a><\/td>\n<td class=\"two\">Piquereau J, Caffin F, <strong>Novotova M<\/strong>, Prola A, Garnier A, Mateo P, Fortin D, Huynh LH, Nicolas V, Alavi MV, Brenner C, Ventura-Clapier R, Veksler V, Joubert F (2012). <a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22406748\")'>Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload.<\/a> <i>Cardiovasc Res<\/i> 94: 408-417.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22781817\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/GPB.jpg\" width=\"75\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\"><strong>Nichtova Z<\/strong>, <strong>Novotova M<\/strong>, Kralova E, Stankovicova T (2012): <a href='javascript:launchRemote(\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22781817\")'>Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol<\/a>. <i>Gen Physiol Biophys<\/i> 31: 141-51.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Plasticity of the membrane systems of cardiac myocytes&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Back Principal Investigator: Marta Novotov\u00e1 Duration: January 2012 &#8211; December 2014 Coordinating Organization: Institute of Molecular Physiology and&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/completed-projects\/vega-2-0116-12\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":199,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/384"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/comments?post=384"}],"version-history":[{"count":7,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/384\/revisions"}],"predecessor-version":[{"id":1616,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/384\/revisions\/1616"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/199"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/media?parent=384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}