{"id":375,"date":"2018-01-10T10:00:35","date_gmt":"2018-01-10T09:00:35","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/en\/?page_id=375"},"modified":"2024-02-16T13:36:14","modified_gmt":"2024-02-16T12:36:14","slug":"apvv-lpp-0441-09","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/completed-projects\/apvv-lpp-0441-09\/","title":{"rendered":"APVV-LPP-0441-09"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>Mechanisms of ryanodine receptor dysregulation&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Back<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Principal Investigator: <a href=\"http:\/\/www.umfg.sav.sk\/ovsb\/en\/people\/researchers\/zahradnikova-a\/\">Alexandra Zahradn\u00edkov\u00e1<\/a><\/h3>\n<h3>Duration: January 2009 &#8211; December 2012<br \/>\nCoordinating Organization: Institute of Molecular Physiology and Genetics SAS, Bratislava<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Annotation:<\/span><\/h3>\n<p>Contraction of cardiac muscle is evoked by calcium release from intracellular stores into the cytoplasm. In a healthy cardiac myocyte, massive calcium release occurs only during the systole in response to processes that follow membrane depolarization. Due to increased calcium release during the diastole that occurs in many cardiac diseases, calcium contents of the stores and systolic contraction are decreased, while the propensity to massive spontaneous calcium release, delayed afterdepolarizations and arrhythmias is increased. The scientific objective of this project is to elucidate the regulation mechanisms of diastolic calcium release via the calcium release channel (RyR), and to define the effects of changes in RyR gating on calcium handling and calcium signaling in the cardiac myocyte. These studies will enable to identify defects of calcium handling in cardiac disease.<br \/>\nThe pedagogical objective of this proposal is to prepare one PhD student for her profession so that she is able to fully employ her talents and find an appropriate career. After obtaining PhD she should be able to find a postdoctoral position in a prestigious laboratory and complete her postdoctoral stay productively. Alternatively, they should be able to get a position outside academia in which she could fully use her knowledge, skills and creativity.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Keywords:<\/span><\/h3>\n<p>Calcium handling, calcium signaling, ventricular myocyte, ryanodine receptor, electrophysiology, mathematical modeling, cardiac disease<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Objectives:<\/span><\/h3>\n<p>The objective of the project is to elucidate molecular mechanisms of ryanodine receptor  regulation during the diastole and to determine the consequences of defective ryanodine receptor modulation on spontaneous diastolic calcium release and excitation-contraction coupling in cardiac diseases. The pedagogical objective is to prepare one PhD student for a successful career.<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publications:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28713282\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1111\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/FrontiersPhysiol-150x51.jpg\" alt=\"FrontiersPhysiol\" width=\"75\" height=\"17\" \/><\/a><\/td>\n<td class=\"two\"><strong>Faltinova A<\/strong>, Tomaskova N, Antalik M, Sevcik J, <strong>Zahradnikova A<\/strong> (2017). <a href='javascript:launchRemote(\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28713282\")'>The N-terminal region of the ryanodine receptor affects channel activation<\/a>. <i>Front Physiol<\/i> 8: 443.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84884535113&amp;partnerID=40&amp;md5=25cd524c2ad6abd283c3ede539303a2e\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-1140\" src=\"http:\/\/confolab.sav.sk\/ovsb\/wp-content\/uploads\/CEJB.jpg\" alt=\"CEJB\" width=\"75\" height=\"55\" \/><\/a><\/td>\n<td class=\"two\"><strong>Faltinova A<\/strong>, <strong>Zahradnikova A<\/strong> (2013): <a href='javascript:launchRemote(\"http:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84884535113&amp;partnerID=40&amp;md5=25cd524c2ad6abd283c3ede539303a2e\")'>Modification of cardiac RYR2 gating by a peptide from the central domain of the RYR2<\/a>. <i>Cent Eur J Biol<\/i> 8: 1164-1171.<\/td>\n<\/tr>\n<tr>\n<td class=\"small\"><a href='javascript:launchRemote(\"http:\/\/cdn.intechopen.com\/pdfs-wm\/22502.pdf\")'><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/cdn.intechopen.com\/books\/images\/1326.jpg\" width=\"75\" height=\"104\" \/><\/a><\/td>\n<td class=\"two\">Bauerova-Hlinkova V,Bauer J, Hostinova E, Gasperik J, Beck K, Borko L, <strong> Faltinova A<\/strong>, <strong>Zahradnikova A<\/strong>, Sevcik J (2011): <a href='javascript:launchRemote(\"http:\/\/cdn.intechopen.com\/pdfs-wm\/22502.pdf\")'>Bioinformatics Domain Structure Prediction and Homology Modeling of Human Ryanodine Receptor 2.<\/a> Editor Mahmood A. Mahdavi. In Bioinformatics-Trends and Methodologies. &#8211; Rijeka, p. 325-352. ISBN 978-953-307-282-1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Mechanisms of ryanodine receptor dysregulation&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Back Principal Investigator: Alexandra Zahradn\u00edkov\u00e1 Duration: January 2009 &#8211; December 2012 Coordinating Organization: Institute of Molecular Physiology and Genetics SAS, Bratislava&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/completed-projects\/apvv-lpp-0441-09\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":199,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/375"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/comments?post=375"}],"version-history":[{"count":3,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/375\/revisions"}],"predecessor-version":[{"id":1614,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/375\/revisions\/1614"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/199"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/media?parent=375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}