{"id":199,"date":"2018-01-08T13:39:31","date_gmt":"2018-01-08T13:39:31","guid":{"rendered":"http:\/\/confolab.sav.sk\/ovsb\/en\/?page_id=199"},"modified":"2024-09-12T10:14:27","modified_gmt":"2024-09-12T08:14:27","slug":"completed-projects","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/completed-projects\/","title":{"rendered":"Completed projects"},"content":{"rendered":"

2017-2022<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\n

International grants:<\/h3>\n<\/td>\n<\/tr>\n

\"mito\"<\/a><\/td>\nEuropean Joint Program for Rare Diseases (EJP-RD) No 40-46300-98-1074
\nFunding to organize the symposium SIRMAMTHERA\u201922 – Mitochondria-associated membranes as a therapeutic target in rare neurodegenerative diseases<\/i><\/a> (26.-27. 10. 2022)
\nPrincipal investigator: Michal Cagalinec<\/a><\/td>\n<\/tr>\n
\"image\"<\/a><\/td>\nJRP\/2019\/836\/RyRinHeart
\nRyRinHeart – Discovery of Ryanodine Receptor Inhibitors for Heart Diseases <\/i><\/a>(2020 \u2013 2022)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a> <\/td>\n<\/tr>\n
\"mito\"<\/a><\/td>\nSASPRO 0063\/01\/02
\nMitochondria-endoplasmic reticulum functional interplay in Wolfram Syndrome: emerging role for heart and brain protection <\/i><\/a> (2015-2018)
\nPrincipal investigator: Michal Cagalinec<\/a><\/td>\n<\/tr>\n
<\/td>\n\n

Slovak Research and Development Agency (APVV):<\/h3>\n<\/td>\n<\/tr>\n

\"image\"<\/a><\/td>\nAPVV-16-0452
\nPPIS – Regulation of pericellular proteolysis: From molecular mechanisms to novel immune cell subsets and therapeutic tools<\/a><\/em> (2017-2021)
\nPrincipal investigator (IMB SAS): Vladim\u00edr Leksa
\nTeam leader at IEE BRC SAS: Alexandra Zahradn\u00edkov\u00e1 jr.<\/a><\/td>\n<\/tr>\n
\"image\"<\/a><\/td>\nAPVV-15-0302
\nCytoarchitecture of calcium signalling of cardiac myocytes in development of myocardial hypertrophy <\/i><\/a>(2016 \u2013 2019)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a> <\/td>\n<\/tr>\n
\"membranes\"<\/a><\/td>\nAPVV-SK-FR-2015-0007
\nEffect of endoplasmic reticulum stress on ultrastructure and metabolism of mammalian cardiomyocytes<\/i><\/a> (2016 \u2013 2017)
\nPrincipal investigator: Marta Novotov\u00e1<\/a><\/td>\n<\/tr>\n
<\/td>\n\n

Grant Agency for Science (VEGA):<\/h3>\n<\/td>\n<\/tr>\n

\"wave\"<\/a><\/td>\nVEGA 2\/0121\/19
\nDominant mutations in Wolfram syndrome: different mechanism to the recessive ones?<\/i><\/a> (2019 \u2013 2022)
\nPrincipal investigator: Michal Cagalinec<\/a><\/td>\n<\/tr>\n
\"wave\"<\/a><\/td>\nVEGA 2\/0091\/19
\nMechanisms of skeletal muscle adaptation to regular exercise in patients with chronic metabolic and inflammatory disease<\/i><\/a> (2019 \u2013 2022)
\nPrincipal investigator: Marta Novotov\u00e1<\/a><\/td>\n<\/tr>\n
\"wave\"<\/a><\/td>\nVEGA 2\/0143\/17
\nDiastolic function of the ryanodine receptor and generation of arrhythmogenic calcium waves<\/i><\/a> (2017 \u2013 2019)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a> (2017); Alexandra Zahradn\u00edkov\u00e1, jr.<\/a> (2018-2019)<\/td>\n<\/tr>\n
\"mito\"<\/a><\/td>\nVEGA 2\/0169\/16
\nMitochondrial dynamics and morphology in transgenic model of Wolfram syndrome: emerging role for heart protection<\/i><\/a> (2016 \u2013 2018)
\nPrincipal investigator: Michal Cagalinec<\/a><\/td>\n<\/tr>\n
\"membranes\"<\/a><\/td>\nVEGA 2\/0110\/15
\nThe effect of myocardial load on distribution of the endoplasmic membrane reticulum of cardiac myocytes<\/i><\/a> (2015 \u2013 2017)
\nPrincipal investigator: Marta Novotov\u00e1<\/a><\/td>\n<\/tr>\n
\"twocolor\"<\/a><\/td>\nVEGA 2\/0095\/15
\nExpression and co-localization of dyadic protein complexes in ventricular myocytes in relation to excitation-contraction coupling ontogenesis<\/i><\/a> (2015 \u2013 2017)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1, jr.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

2012-2015<\/h2>\n\n\n\n\n\n\n\n
<\/td>\n\n

Slovak Research and Development Agency (APVV):<\/h3>\n<\/td>\n<\/tr>\n

\"image\"<\/a><\/td>\nAPVV-0721-10
\nMyocardial remodelling – the role of calcium signalling (REMOD) <\/i><\/a>(2011 \u2013 2014)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n
\"mito3\"<\/a><\/td>\nAPVV-SK-FR-0021-11
\nEnergetic cross-talk and cytoarchitecture of cardiac myocytes. Role of the mitochondrial protein OPA1.<\/i><\/a> (2012 \u2013 2013)
\nPrincipal investigator: Marta Novotov\u00e1<\/a><\/td>\n<\/tr>\n
\"APVV4b\"<\/a><\/td>\nAPVV-LPP-0441-09
\nMechanisms of ryanodine receptor dysregulation<\/i><\/a> (2009 \u2013 2012)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n
<\/td>\n\n

Grant Agency for Science (VEGA):<\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n
\"molecule\"<\/a><\/td>\nVEGA 2\/0148\/14
\nStructure-function relationships of the ryanodine receptor <\/i><\/a>(2014-2016)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n
\"image\"<\/a><\/td>\nVEGA 2\/0147\/14
\nDevelopment of dyadic calcium signaling during postnatal maturation of ventricular myocytes<\/i><\/a> (2014-2016)
\nPrincipal investigator: Ivan Zahradn\u00edk<\/a><\/td>\n<\/tr>\n
\"membranes\"<\/a><\/td>\nVEGA 2\/0116\/12
\nPlasticity of the membrane systems of cardiac myocytes<\/i><\/a> (2012 \u2013 2014)
\nPrincipal investigator: Marta Novotov\u00e1<\/a><\/td>\n<\/tr>\n
\"conductance\"<\/a><\/td>\nVEGA 2\/0203\/11
\nSarcolemmal and membrane conductance dynamics in cardiac myocytes<\/i><\/a> (2011 \u2013 2013)
\nPrincipal investigator: Ivan Zahradn\u00edk<\/a><\/td>\n<\/tr>\n
\"image\"<\/a><\/td>\nVEGA 2\/0197\/11
\nMechanisms of communication among ion channels of cardiomyocyte dyad<\/i><\/a> (2011 \u2013 2013)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1, jr.<\/a>, Jana Pavelkov\u00e1<\/a><\/td>\n<\/tr>\n
\"wave\"<\/a><\/td>\nVEGA 2\/0190\/10
\nMechanisms of regulation of the diastolic activity of the ryanodine receptor<\/i><\/a> (2010 \u2013 2012)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Selected older projects<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\n

International grants:<\/h3>\n<\/td>\n<\/tr>\n

\"image\"<\/a><\/td>\nLSHM-CT-2005-018833
\nGenomics of cardiomyocyte signalling to treat and prevent heart failure <\/i><\/a>(2006-2010)
\nCoordinator: Gerd Hasenfuss, University of G\u00f6ttingen
\nTeam leader: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n
\"wave\"<\/a><\/td>\nLSHM-CT-2005-018802
\nControl of Intracellular Calcium in Arrhythmias<\/i><\/a> (2006-2009)
\nCoordinator: Burkert Pieske, University of G\u00f6ttingen \/ University of Graz
\nTeam leader: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n
\"wave\"<\/a><\/td>\nNIH FIRCA RO3 TW005543\/2
\nReorganization of calcium signaling in heart failure <\/i><\/a>(2005-2008)
\nPrincipal Investigator: Sandor Gyorke, Ohio State University, Columbus, OH, USA
\nInternational Collaborator: Alexandra Zahradn\u00edkov\u00e1<\/a>, Ivan Zahradn\u00edk<\/a><\/td>\n<\/tr>\n
\"image\"<\/a><\/td>\nNIH FIRCA RO3 TW005543\/1
\nCalcium signalling in cardiac excitation-contraction coupling<\/i><\/a> (2001-2004)
\nPrincipal Investigator: Sandor Gyorke, Texas Tech University, Lubbock, TX, USA
\nInternational Collaborator: Alexandra Zahradn\u00edkov\u00e1<\/a>, Ivan Zahradn\u00edk<\/a><\/td>\n<\/tr>\n
\"image\"<\/a><\/td>\nHHMI-55000343
\nMolecular mechanisms of calcium signaling in cardiac excitation-contraction coupling <\/i><\/a>(2001-2005)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n
\"APVV4b\"<\/a><\/td>\nHHMI-75195547801
\nRyanodine receptor and excitation-contraction coupling <\/i><\/a>(1995-2000)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n
<\/td>\n\n

Slovak Research and Development Agency (APVV):<\/h3>\n<\/td>\n<\/tr>\n

\"myo\"<\/a><\/td>\nAPVV-SK-CZ-0172-09
\nCell and molecular physiology of cardiomyocytes<\/i><\/a> (2010 \u2013 2011)
\nPrincipal investigator: Alexandra Zahradn\u00edkov\u00e1<\/a><\/td>\n<\/tr>\n
\"RyR\"<\/a><\/td>\nAPVV-0139-06
\nSaFRyR: Structure-function relationships of the ryanodine receptor domains involved in CPVT arrhythmias<\/i><\/a> (2007 \u2013 2009)
\nPrincipal Investigator: Jozef \u0160ev\u010d\u00edk<\/td>\n<\/tr>\n
\"image\"<\/a><\/td>\nAPVT-51-031104
\nMechanism of excitation-contraction coupling in normal and failing mammalian myocardium <\/i><\/a>(2005 \u2013 2007)
\nPrincipal investigator: Ivan Zahradn\u00edk<\/a><\/td>\n<\/tr>\n
<\/td>\n\n

Other domestic grants:<\/h3>\n<\/td>\n<\/tr>\n

<\/td>\n\u201e\u0160tef\u00e1nik\u201c \u2013 No. 11
\nArchitecture cellulaire et transferts d\u00b4energie dans les cellules cardiaques et musculaires <\/i> (2004 – 2005)
\nPrincipal investigator: Marta Novotov\u00e1<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

2017-2022 International grants: European Joint Program for Rare Diseases (EJP-RD) No 40-46300-98-1074 Funding to organize the symposium SIRMAMTHERA\u201922 – Mitochondria-associated membranes as a therapeutic target…\u010d\u00edta\u0165 \u010falej »<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":20,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/199"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/comments?post=199"}],"version-history":[{"count":57,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/199\/revisions"}],"predecessor-version":[{"id":1713,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/199\/revisions\/1713"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/20"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/media?parent=199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}