{"id":1694,"date":"2024-09-06T09:29:08","date_gmt":"2024-09-06T07:29:08","guid":{"rendered":"https:\/\/confolab.sav.sk\/ovsb\/en\/?page_id=1694"},"modified":"2024-09-11T15:56:56","modified_gmt":"2024-09-11T13:56:56","slug":"cost-ca23156","status":"publish","type":"page","link":"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/active-projects\/cost-ca23156\/","title":{"rendered":"COST CA23156"},"content":{"rendered":"<p><script type=\"text\/javascript\">\n<!--\nfunction launch(newURL, newName, newFeatures, orgName) {\n  var remote = open(newURL, newName, newFeatures);\n  if (remote.opener == null)\n    remote.opener = window;\n  remote.opener.name = orgName;\n  return remote;\n}\n\nfunction launchRemote(name) {\n  var address =  name;\n  myRemote = launch(address ,\n                    \"Okno\",\n                    \"height=500, width=850, left=50, top=50, alwaysLowered=0, alwaysRaised=0, channelmode=0, dependent=0, directories=0, fullscreen=0, hotkeys=1, location=0, menubar=0, resizable=0, scrollbars=0, status=0, titlebar=1, toolbar=0, z-lock=0\",\n                    \"myWindow\");\n}\n\/\/ -->>\n<\/script><\/p>\n<h2>European Network for Sigma-1 Receptor as a Therapeutic Opportunity (SIGMA-1EUROPE)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<button onclick=\"goBack()\">Back<\/button> <\/h2>\n<p><script>\t \t \nfunction goBack() { window.history.go(-1); }\t \t \n<\/script><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"2\">\n<tbody>\n<tr>\n<td>\n<h3>Principal Investigator: Tangui Maurice<\/h3>\n<h3>Principal Investigator (SK): <a href=\"http:\/\/confolab.sav.sk\/ovsb\/en\/people\/researchers\/rndr-michal-cagalinec-phd\/\">Michal Cagalinec<\/a><br \/>\nParticipating as Secondary Proposer<\/h3>\n<h3>Duration: 2024 &#8211; 2028<br \/>\nCoordinating Organization: M\u00e9canismes mol\u00e9culaires dans les d\u00e9mences neurod\u00e9g\u00e9n\u00e9ratives (MMDN), Institut national de la Sante et de la Recherche Medicale INSERM, Montpellier, France<br \/>\nCoordinating Organization (SK): Institute of Experimental Endocrinology BRC SAS<\/h3>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Annotation:<\/span><\/h3>\n<p>The sigma-1 receptor (S1R) is a ligand-regulated endoplasmic reticulum chaperone protein and a target for innovative compounds for the treatment of neurodegenerative and inflammatory diseases, cancers and pain diseases. The SIGMA-1 EUROPE network will bring together disciplines and expertises across Europe to advance the exploration and identification of the role of the Sigma-1 receptor in physiology and pathologies, to design innovative S1R ligands for cellular biology and medicine, and ultimately to train young reserachers and innovators to revise our views of the diseases, to think out-of-the-box and explore novel and innovative therapeutic opportunities.\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Keywords:<\/span><\/h3>\n<p>Pharmacology, Drug development, Translational training, Cytoprotection, Pain<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Objectives:<\/span><\/h3>\n<p>1. Drug design, modelling, radiotracers<br \/>\n2. S1R in neurodegenerative, inflammatory, cancer and cardiometabolic diseases<br \/>\n3. Establishment of SOPs for in vitro and in vivo models to assess S1R ligands<br \/>\n4. Industry strategies requirement for drug development<br \/>\n5. Dissemination, Communication and Outreach\n<\/td>\n<\/tr>\n<tr>\n<td>\n<h3><span class=\"H3\">Publications:<\/span><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table class=\"list\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>European Network for Sigma-1 Receptor as a Therapeutic Opportunity (SIGMA-1EUROPE)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Back Principal Investigator: Tangui Maurice Principal Investigator (SK): Michal Cagalinec Participating as Secondary Proposer Duration: 2024&#8230;<span class=\"excerpt_more\"><a href=\"https:\/\/confolab.sav.sk\/ovsb\/en\/projects\/active-projects\/cost-ca23156\/\">\u010d\u00edta\u0165 \u010falej &raquo;<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/1694"}],"collection":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/comments?post=1694"}],"version-history":[{"count":5,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/1694\/revisions"}],"predecessor-version":[{"id":1703,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/1694\/revisions\/1703"}],"up":[{"embeddable":true,"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"https:\/\/confolab.sav.sk\/ovsb\/en\/wp-json\/wp\/v2\/media?parent=1694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}