Older publications

In this section publications illustrating the main objectives of DMCR laboratories are shown. Papers older than 5 years are shown.

	Iaparov B, Moskvin AS, Zahradnik I, Zahradnikova A (2019): Stochastic and deterministic approaches to modelling calcium release in cardiac myocytes at different spatial arrangements of ryanodine receptors. Eur Biophys J 48: 579–584 doi: 10.1007/s00249-019-01378-z.
	Skrabanek P, Zahradnikova A Jr (2019): Automatic assessment of the cardiomyocyte development stages from confocal microscopy images using deep convolutional networks. PLoS One 14: e0216720, doi: 10.1371/journal.pone.0216720.
	Sramkova M, Kozics K, Masanova V, Uhnakova I, Razga F, Nemethova V, Mazancova P, Kapka-Skrzypczak L, Kruszewski M, Novotova M, Puntes VF, Gabelova A (2019): Kidney nanotoxicity studied in human renal proximal tubule epithelial cell line TH1. Mutat Res 845: 403017 doi: 10.1016/j.mrgentox.2019.01.012.
	Cagalinec M, Zahradnikova A, Zahradnikova A Jr, Kovacova D, Paulis L, Kurekova S, Hotka M, Pavelkova J, Plaas M, Novotova M, Zahradnik I (2019). Calcium signaling and contractility in cardiac myocyte of wolframin deficient rats. Front Physiol 10: 172, doi: 10.3389/fphys.2019.00172.
	Ohradanova-Repic A, Machacek C, Donner C, Muhlgrabner V, Petrovcikova E, Zahradnikova A Jr, Vicikova K, Horejsi V, Stockinger H, Leksa V (2019): The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosisy. J Leukoc Biol. 105: 519-530, doi: 10.1002/JLB.1AB0417-160RR.
	Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey MA, Cagalinec M, Mandel M, Zeb A, Liiv M, Kaasik A (2019): Miro proteins prime mitochondria for Parkin translocation and mitophagy. EMBO J 38: e99384, doi: 10.15252/embj.201899384.
	Marcek Chorvatova A, Kirchnerova J, Cagalinec M, Mateasik A, Chorvat D Jr (2019): Spectrally and spatially resolved laser-induced photobleaching of endogenous flavin fluorescence in cardiac myocytes. Cytometry Part A 95: 13-23, doi: 10.1002/cyto.a.23591.
	Prola A, Nichtova Z, Pires Da Silva J, Piquereau J, Monceaux K, Guilbert A, Gressette M, Ventura-Clapier R, Garnier A, Zahradnik I, Novotova M, Lemaire C (2019): Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes. Cardiovasc Res 115: 328-342, doi: 10.1093/cvr/cvy197.
	Martinkova N, Pikula J, Zukal J, Kovacova V, Bandouchova H, Bartonicka T, Botvinkin AD, Brichta J, Dundarova H, Kokurewicz T, Irwin NR, Linhart P, Orlov OL, Piacek V, Skrabanek P, Tiunov MP, Zahradnikova A Jr (2018): Hibernation temperature-dependent Pseudogymnoascus destructans infection intensity in Palearctic bats. Virulence 9: 1734-1750.
	Harazim M, Horacek I, Jakesova L, Luermann K, Moravec JC, Morgan S, Pikula J, Sosik P, Vavrusova Z, Zahradnikova A Jr, Zukal J, Martinkova N (2018): Natural selection in bats with historical exposure to white-nose syndrome. BMC Zoology 3: 8.
	Bandouchova H, Bartonicka T, Berkova H, Brichta J, Kokurewicz T, Kovacova V, Linhart P, Piacek V, Pikula J, Zahradnikova A Jr, Zukal J (2018): Alterations in the health of hibernating bats under pathogen pressure. Sci Rep 8: 6067.
	Zahradnikova A Jr, Kovacova V, Martinkova N, Orlova MV, Orlov OL, Piacek V, Zukal J, Pikula J (2018): Historic and geographic surveillance of Pseudogymnoascus destructans possible from collections of bat parasites. Transbound Emerg Dis 65: 303-308.
	Hotka M, Zahradnik I (2017): Reconstruction of membrane current by deconvolution and its application to membrane capacitance measurements in cardiac myocytes. PLoS One 12: e0188452.
	Mackova K, Zahradnikova A Jr, Hotka M, Hoffmannova B, Zahradnik I, Zahradnikova A (2017). Calcium release-dependent inactivation precedes formation of the tubular system in developing rat cardiac myocytes. Eur Biophys J 46: 691-703.
	Wang YY, Mesirca P, Marques-Sule E, Zahradnikova A Jr, Villejoubert O, D’Ocon P, Ruiz C, Domingo D, Zorio E, Mangoni ME, Benitah JP, Gómez AM (2017). RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism. JCI Insight 2: e91872.
	Faltinova A, Tomaskova N, Antalik M, Sevcik J, Zahradnikova A (2017). The N-terminal region of the ryanodine receptor affects channel activation. Front Physiol 8: 443.
	Ragni CV, Diguet N, Le Garrec JF, Novotova M, Resende TP, Pop S, Charon N, Guillemot L, Kitasato L, Badouel C, Dufour A, Olivo-Marin JC, Trouvé A, McNeill H, Meilhac SM. (2017): Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun 27: 14582.
	Misuth M, Joniova J, Horvath D, Dzurova L, Nichtova Z, Novotova M, Miskovsky P, Stroffekova K, Huntosova V. (2017): The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. Cell Signal 34: 11–22.
	Huntosova V, Novotova M, Nichtova Z, Balogova L, Maslanakova M, Petrovajova D, Stroffekova K (2017): Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. Toxicol In Vitro 40: 184–195.
	Novotova M, Tarabova B, Tylkova L, Ventura-Clapier R, Zahradnik I (2016): Ultrastructural remodelling of slow skeletal muscle fibres in creatine kinase deficient mice: a quantitative study. Gen Physiol Biophys 35: 477–486.
	Cagalinec M, Liiv M, Hodurova Z, Hickey MA, Vaarmann A, Mandel M, Zeb A, Choubey V, Kuum M, Safiulina D, Vasar E, Veksler V, Kaasik A (2016): Role of mitochondrial dynamics in neuronal development: Mechanism for wolfram syndrome. PLoS Biol 14: e1002511.
	Zukal J, Bandouchova H, Brichta J, Cmokova A, Jaron KS, Kolarik M, Kovacova V, Kubatova A, Novakova A, Orlov O, Pikula J, Presetnik P, Suba J, Zahradnikova A Jr, Martinkova N (2016): White-nose syndrome without borders: Pseudogymnoascus destructans infection tolerated in Europe and Palearctic Asia but not in North America. Sci Rep 6: 19829.
	Lucan RK, Bandouchova H, Bartonicka T, Pikula J, Zahradnikova A Jr, Zukal J, Martinkova N (2016): Ectoparasites may serve as vectors for the white-nose syndrome fungus. Parasit Vectors 9: 16.
	Petrovic P, Valent I, Cocherova E, Pavelkova J, Zahradnikova A (2015): Ryanodine receptor gating controls generation of diastolic calcium waves in cardiac myocytes. J Gen Physiol 145: 489-511.
	Hotka M, Zahradnik I (2014): Correction of the cross-talk error in cell membrane impedance analysis. In: YBERC 2014. Bratislava, Slovak Republic. Proceedings of The 6th International Young Biomedical Engineers and Researchers Conference, July 2-4, 2014, p. 31-34. ISBN 978–80–971697–0–1.
	Hotka M, Zahradnik I (2014): High resolution measurement of electrical impedance of excitable cells. In: Adept 2014. 2nd International Conference on Advances in Electronic and Photonic Technologies, Tatranská Lomnica, June 1-4, 2014, Proceedings of Adept, p. 55-58.
	Borko L, Bauerova-Hlinkova V, Hostinova E, Gasparik J, Beck K, Lai FA, Zahradnikova A, Sevcik J (2014): Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias. Acta Cryst D70: 2897–2912.
	Caffin F, Prola A, Piquereau J, Novotova M, David DJ, Garnier A, Fortin D, Alavi M, Veksler V, Ventura-Clapier R, Joubert F (2013): Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice. J Physiol 591: 6017-37.
	Faltinova A, Zahradnikova A (2013): Modification of cardiac RYR2 gating by a peptide from the central domain of the RYR2. Cent Eur J Biol 8: 1164-1171.
	Borko L, Kostan J, Zahradnikova A, Pevala V, Gasperik J, Hostinova E, Urbanikova L, Carugo KD, Bauerova Hlinkova V, Sevcik J (2013): Human cardiac ryanodine receptor: Preparation, crystallization and preliminary X-ray analysis of the N-terminal region. Protein Pept Lett 20: 1211-6.
	Misak A, Grman M, Malekova L, Novotova M, Markova J, Krizanova O, Ondrias K, Tomaskova Z (2013): Mitochondrial chloride channels: electrophysiological characterization and pH induction of channel pore dilation. Eur Biophys J 42: 709-20.
	Janicek R, Hotka M, Zahradnikova-Jr A, Zahradnikova A, Zahradnik I (2013): Quantitative analysis of calcium spikes in noisy fluorescent background. PLoS One 8: e64394.
	Piquereau J, Caffin F, Novotova M, Lemaire C, Veksler V, Garnier A, Ventura-Clapier R, Joubert F (2013): Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell? Front Physiol 4: 102.
	Zahradnikova A, Zahradnik I (2012). Construction of calcium release sites in cardiac myocytes. Front Physiol 3: 322.
	Nichtova Z, Novotova M, Kralova E, Stankovicova T (2012): Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol. Gen Physiol Biophys 31: 141-51.
	Janicek R, Zahradnikova-Jr A, Polakova E, Pavelkova J, Zahradnik I, Zahradnikova A (2012): Calcium spike variability in cardiac myocytes results from activation of small cohorts of RYR2 channels. J Physiol 590: 5091-5106.
	Tencerova B, Zahradnikova A, Gaburjakova J, Gaburjakova M (2012): Luminal Ca2+ controls activation of the cardiac ryanodine receptor by ATP. J Gen Physiol 140: 93-108.
	Piquereau J, Caffin F, Novotova M, Prola A, Garnier A, Mateo P, Fortin D, Huynh LH, Nicolas V, Alavi MV, Brenner C, Ventura-Clapier R, Veksler V, Joubert F (2012). Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Cardiovasc Res 94: 408-417.
	Piquereau J, Novotova M, Fortin D, Garnier A, Ventura-Clapier R, Veksler V, Joubert F (2010). Postnatal development of mouse heart: formation of energetic microdomains. J Physiol.588: 2443-54.
	Zahradnikova A, Valent I, Zahradnik I (2010): Frequency and release flux of calcium sparks in rat cardiac myocytes: a relation to RYR gating. J Gen Physiol 136: 101-116.
	Parulek J, Sramek M, Cerveansky M, Novotova M, Zahradnik I (2009). A cell architecture modeling system based on quantitative ultrastructural characteristics. Methods Mol Biol. 500: 289-312.
	Parulek J, Sramek M, Zahradnik I (2009). GeomCell Design of Cell Geometry. Recent Advances in the 3d Physiological Human, N. Magnenat-Thalmann et al. (eds.), Springer-Verlag London Ltd, p. 21-36.
	Polakova E, Zahradnikova A Jr, Pavelkova J, Zahradnik I, Zahradnikova A (2008). Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes. J Physiol. 586: 3839-3854.
	Joubert F, Wilding JR, Fortin D, Domergue-Dupont V, Novotova M, Ventura-Clapier R, Veksler V (2008). Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure. J Physiol. 586: 5181-5192.
	Zahradnik I, Minarovic I, Zahradnikova A (2008). Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. J Pharmacol Exp Ther. 324:977-984.
	Zahradnikova A Jr, Polakova E, Zahradnik I, Zahradnikova A (2007). Kinetics of calcium spikes in rat cardiac myocytes. J Physiol 578: 677-691.
	Novotova M, Pavlovicova M, Veksler VI, Ventura-Clapier R, Zahradnik I (2006). Ultrastructural remodeling of fast skeletal muscle fibers induced by invalidation of creatine kinase. Am J Physiol Cell Physiol. 291: C1279-1285.
	Zahradnik I, Gyorke S, Zahradnikova A (2005). Calcium activation of ryanodine receptor channels–reconciling RyR gating models with tetrameric channel structure. J Gen Physiol. 126: 515-527.
	Zahradnikova A, Kubalova Z, Pavelkova J, Gyorke S, Zahradnik I (2004). Activation of calcium release assessed by calcium release-induced inactivation of calcium current in rat cardiac myocytes. Am J Physiol Cell Physiol. 286: C330-41.
	Zahradnikova A, Dura M, Gyorke I, Escobar AL, Zahradnik I, Gyorke S (2003). Regulation of dynamic behavior of cardiac ryanodine receptor by Mg2+ under simulated physiological conditions. Am J Physiol Cell Physiol. 285: C1059-1070.
	Novotova M, Zahradnik I, Brochier G, Pavlovicova M, Bigard X, Ventura-Clapier R (2002). Joint participation of mitochondria and sarcoplasmic reticulum in the formation of tubular aggregates in gastrocnemius muscle of CK-/- mice. Eur J Cell Biol. 81: 101-106.
	Kaasik A, Veksler V, Boehm E, Novotova M, Minajeva A, Ventura-Clapier R (2001). Energetic crosstalk between organelles: architectural integration of energy production and utilization. Circ Res. 89: 153-159.
	Zahradnikova A, Zahradnik I, Gyorke I, Gyorke S (1999). Rapid activation of the cardiac ryanodine receptor by submillisecond calcium stimuli. J Gen Physiol. 114: 787-798.
	Zahradnikova A, Zahradnik I (1996). A minimal gating model for the cardiac calcium release channel. Biophys J. 71: 2996-3012.