Department of Cellular Cardiology, IEE BRC SLOVENSKY contactcontact

Completed projects

2017-2022

International grants:
mito European Joint Program for Rare Diseases (EJP-RD) No 40-46300-98-1074
Funding to organize the symposium SIRMAMTHERA’22 – Mitochondria-associated membranes as a therapeutic target in rare neurodegenerative diseases (26.-27. 10. 2022)
Principal investigator: Michal Cagalinec
image JRP/2019/836/RyRinHeart
RyRinHeart – Discovery of Ryanodine Receptor Inhibitors for Heart Diseases (2020 – 2022)
Principal investigator: Alexandra Zahradníková
mito SASPRO 0063/01/02
Mitochondria-endoplasmic reticulum functional interplay in Wolfram Syndrome: emerging role for heart and brain protection (2015-2018)
Principal investigator: Michal Cagalinec

Slovak Research and Development Agency (APVV):
image APVV-16-0452
PPIS – Regulation of pericellular proteolysis: From molecular mechanisms to novel immune cell subsets and therapeutic tools (2017-2021)
Principal investigator (IMB SAS): Vladimír Leksa
Team leader at IEE BRC SAS: Alexandra Zahradníková jr.
image APVV-15-0302
Cytoarchitecture of calcium signalling of cardiac myocytes in development of myocardial hypertrophy (2016 – 2019)
Principal investigator: Alexandra Zahradníková
membranes APVV-SK-FR-2015-0007
Effect of endoplasmic reticulum stress on ultrastructure and metabolism of mammalian cardiomyocytes (2016 – 2017)
Principal investigator: Marta Novotová

Grant Agency for Science (VEGA):
wave VEGA 2/0121/19
Dominant mutations in Wolfram syndrome: different mechanism to the recessive ones? (2019 – 2022)
Principal investigator: Michal Cagalinec
wave VEGA 2/0091/19
Mechanisms of skeletal muscle adaptation to regular exercise in patients with chronic metabolic and inflammatory disease (2019 – 2022)
Principal investigator: Marta Novotová
wave VEGA 2/0143/17
Diastolic function of the ryanodine receptor and generation of arrhythmogenic calcium waves (2017 – 2019)
Principal investigator: Alexandra Zahradníková (2017); Alexandra Zahradníková, jr. (2018-2019)
mito VEGA 2/0169/16
Mitochondrial dynamics and morphology in transgenic model of Wolfram syndrome: emerging role for heart protection (2016 – 2018)
Principal investigator: Michal Cagalinec
membranes VEGA 2/0110/15
The effect of myocardial load on distribution of the endoplasmic membrane reticulum of cardiac myocytes (2015 – 2017)
Principal investigator: Marta Novotová
twocolor VEGA 2/0095/15
Expression and co-localization of dyadic protein complexes in ventricular myocytes in relation to excitation-contraction coupling ontogenesis (2015 – 2017)
Principal investigator: Alexandra Zahradníková, jr.

2012-2015

Slovak Research and Development Agency (APVV):
image APVV-0721-10
Myocardial remodelling – the role of calcium signalling (REMOD) (2011 – 2014)
Principal investigator: Alexandra Zahradníková
mito3 APVV-SK-FR-0021-11
Energetic cross-talk and cytoarchitecture of cardiac myocytes. Role of the mitochondrial protein OPA1. (2012 – 2013)
Principal investigator: Marta Novotová
APVV4b APVV-LPP-0441-09
Mechanisms of ryanodine receptor dysregulation (2009 – 2012)
Principal investigator: Alexandra Zahradníková

Grant Agency for Science (VEGA):
molecule VEGA 2/0148/14
Structure-function relationships of the ryanodine receptor (2014-2016)
Principal investigator: Alexandra Zahradníková
image VEGA 2/0147/14
Development of dyadic calcium signaling during postnatal maturation of ventricular myocytes (2014-2016)
Principal investigator: Ivan Zahradník
membranes VEGA 2/0116/12
Plasticity of the membrane systems of cardiac myocytes (2012 – 2014)
Principal investigator: Marta Novotová
conductance VEGA 2/0203/11
Sarcolemmal and membrane conductance dynamics in cardiac myocytes (2011 – 2013)
Principal investigator: Ivan Zahradník
image VEGA 2/0197/11
Mechanisms of communication among ion channels of cardiomyocyte dyad (2011 – 2013)
Principal investigator: Alexandra Zahradníková, jr., Jana Pavelková
wave VEGA 2/0190/10
Mechanisms of regulation of the diastolic activity of the ryanodine receptor (2010 – 2012)
Principal investigator: Alexandra Zahradníková

Selected older projects

International grants:
image LSHM-CT-2005-018833
Genomics of cardiomyocyte signalling to treat and prevent heart failure (2006-2010)
Coordinator: Gerd Hasenfuss, University of Göttingen
Team leader: Alexandra Zahradníková
wave LSHM-CT-2005-018802
Control of Intracellular Calcium in Arrhythmias (2006-2009)
Coordinator: Burkert Pieske, University of Göttingen / University of Graz
Team leader: Alexandra Zahradníková
wave NIH FIRCA RO3 TW005543/2
Reorganization of calcium signaling in heart failure (2005-2008)
Principal Investigator: Sandor Gyorke, Ohio State University, Columbus, OH, USA
International Collaborator: Alexandra Zahradníková, Ivan Zahradník
image NIH FIRCA RO3 TW005543/1
Calcium signalling in cardiac excitation-contraction coupling (2001-2004)
Principal Investigator: Sandor Gyorke, Texas Tech University, Lubbock, TX, USA
International Collaborator: Alexandra Zahradníková, Ivan Zahradník
image HHMI-55000343
Molecular mechanisms of calcium signaling in cardiac excitation-contraction coupling (2001-2005)
Principal investigator: Alexandra Zahradníková
APVV4b HHMI-75195547801
Ryanodine receptor and excitation-contraction coupling (1995-2000)
Principal investigator: Alexandra Zahradníková

Slovak Research and Development Agency (APVV):
myo APVV-SK-CZ-0172-09
Cell and molecular physiology of cardiomyocytes (2010 – 2011)
Principal investigator: Alexandra Zahradníková
RyR APVV-0139-06
SaFRyR: Structure-function relationships of the ryanodine receptor domains involved in CPVT arrhythmias (2007 – 2009)
Principal Investigator: Jozef Ševčík
image APVT-51-031104
Mechanism of excitation-contraction coupling in normal and failing mammalian myocardium (2005 – 2007)
Principal investigator: Ivan Zahradník

Other domestic grants:
„Štefánik“ – No. 11
Architecture cellulaire et transferts d´energie dans les cellules cardiaques et musculaires (2004 – 2005)
Principal investigator: Marta Novotová