Recent publications

In this section the papers published in the last five years are shown. The list shows both, publications conceived in the department, and publications where members of the department collaborated with colleagues.     

FrontiersPhysiol Baglaeva I, Iaparov B, Zahradnik I, Zahradnikova A (2023). Analysis of noisy transient signals based on Gaussian process regression. Biophys J 122: 451–459. doi: 10.1016/j.bpj.2023.01.003.
FrontiersPhysiol Koci J, Novotova M, Slavikova M, Klempa B, Zahradnik I (2022). SARS-CoV-2 Exploits Non-Canonical Autophagic Processes to Replicate, Mature, and Egress the Infected Vero E6 Cells. Pathogens 11: 1535. doi: 10.3390/pathogens11121535.
FrontiersPhysiol Iaparov B, Baglaeva I, Zahradnik I, Zahradnikova A (2022). Magnesium ions moderate calcium-induced calcium release in cardiac calcium release sites by binding to ryanodine receptor activation and inhibition sites. Front Physiol 12: 805956. doi: 10.3389/fphys.2021.805956.
Grimbert L, Sanz MN, Gressette M, Rucker-Martin C, Novotova M, Solgadi A, Karoui A, Gomez S, Bedouet K, Jacquet E, Lemaire C, Veksler V, Mericskay M, Ventura-Clapier R, Piquereau JM, Garnier A (2021): Spatiotemporal AMPK alpha 2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only. Biol Sex Differ, vol 12: 52. doi: 10.1186/s13293-021-00394-z.
Marcek Chorvatova A, Cagalinec M, Chorvat D Jr (2021): Time-resolved imaging of mitochondrial flavin fluorescence and its applications for evaluating the oxidative state in living cardiac cells. Mitochondrial Medicine. Methods in Molecular Biology, vol 2275, chapter 26: 403-414. Humana, New York, NY. Volume 1: Targeting Mitochondria, Weissig V., Edeas M. (eds), ISBN 978-1-0716-1262-0, doi: 10.1007/978-1-0716-1262-0_26.
Circ Res Yin L, Zahradnikova A Jr, Rizzetto R, Boncompani S, Rabesahala de Meritens C, Zhang Y, Joanne P, Marques Sule E, Aguilar-Torres Y, Fernandez-Tenorio M, Villejoubert O, Li L, Wang YY, Mateo P, Nicolas V, Gerbaud P, Lai FA, Perrier R, Alvarez JL, Niggli E, Valdivia HH, Valdivia CR, Ramos-Franco J, Zorio E, Zissimopoulos S, Protasi F, Benitah JP, Gomez AM (2021): Impaired binding to junctophilin2 and nanostructural alteration in CPVT mutation. Circ Res 129: e35-e52 doi: 10.1161/CIRCRESAHA.121.319094.
JGP Iaparov B, Zahradnik I, Moskvin AS, Zahradnikova A (2021): In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes. J Gen Physiol 153: e202012685 doi: 10.1085/jgp.202012685.
Kurekova S, Plaas M, Cagalinec M (2020): Short Communication: Lack of functional wolframin causes drop in plasmalemmal sodium-calcium exchanger type 1 expression at early stage in rat model of Wolfram syndrome. Gen Physiol Biophys 39: 499–503 doi: 10.4149/gpb_2020017.
Prog Biophys Mol Biol Bebarova M, Pasek M, Zahradnik I (2020): Editorial: Toward more accurate data in cardiac cellular electrophysiology. Prog Biophys Mol Biol 157: 1-2 doi: 10.1016/j.pbiomolbio.2020.06.006.
Front Cell Dev Biol Piquereau J, Veksler V, Novotova M, Ventura-Clapier R (2020): Energetic interactions between subcellular organelles in striated muscles. Front Cell Dev Biol 8: 581045 doi: 10.3389/fcell.2020.581045.
Prog Biophys Mol Biol Iaparov B, Zahradnik I, Moskvin AS, Zahradnikova A (2020): Synergy of calcium release site determinants in control of calcium release events in cardiac myocytes. bioRXiv : doi:
PLoSOne Leskova A, Labajova M, Krausko M, Zahradnikova A Jr, Baluska F, Micieta K, Turňa K, Jasik J (2020): Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1. PLoS One 15: e0237448, doi: 10.1371/journal.pone.0237448. eCollection 2020.
Prog Biophys Mol Biol Selc M, Razga F, Nemethova V, Mazancova P, Ursinyova M, Novotova M, Kopecka K, Gabelova A, Babelova A (2020): Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells. RSC Adv 10: 23916–23929 doi: 10.1039/d0ra03133j.
Prog Biophys Mol Biol Zahradnikova A, Iaparov B, Zahradnik I (2020): The problem of accuracy in single-channel open probability measurements. Prog Biophys Mol Biol 157: 94-106 doi: 10.1016/j.pbiomolbio.2020.05.002.
SciRep Novotova M, Zahradnikova A Jr, Nichtova Z, Kovac R, Kralova E, Stankovicova T, Zahradnikova A, Zahradnik I (2020): Structural variability of dyads relates to calcium release in rat ventricular myocytes. Sci Rep 10: 8076 doi: 10.1038/s41598-020-64840-5.
Pires Da Silva J, Monceaux K, Guilbert A, Gressette M, Piquereau J, Novotova M, Ventura-Clapier R, Garnier A, Lemaire C (2020): SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy. Cells. 9: E426 doi: 10.3390/cells9020426.
Hotka M, Cagalinec M, Hilber K, Hool L, Boehm S, Kubista H (2020): L-type Ca2+ channel-mediated Ca2+ influx adjusts neuronal mitochondrial function to physiological and pathophysiological conditions. Sci Signal. 13: eaaw6923 doi: 10.1126/scisignal.aaw6923.
Ebner J, Cagalinec M, Kubista H, Todt H, Szabo PL, Kiss A, Podesser BK, Cserne Szappanos H, Hool LC, Hilber K, Koenig X (2020): Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Cav1.2 channel modulation under basal conditions. Pflugers Arch. 472: 61-74 doi: 10.1007/s00424-019-02335-7.
Duranova H, Pozgajova M, Novotova M, Lukac N, Knazicka Z (2019): Fission yeast schizosaccharomyces pombe as a model system for ultrastructural investigations using transmission electron microscopy. J Microbiol Biotech Food Sci 9: 160–165 doi: 10.15414/jmbfs.2019.9.1.160-165.
Eur Biophys J Iaparov B, Moskvin AS, Zahradnik I, Zahradnikova A (2019): Stochastic and deterministic approaches to modelling calcium release in cardiac myocytes at different spatial arrangements of ryanodine receptors. Eur Biophys J 48: 579–584 doi: 10.1007/s00249-019-01378-z.
PLoSOne Skrabanek P, Zahradnikova A Jr (2019): Automatic assessment of the cardiomyocyte development stages from confocal microscopy images using deep convolutional networks. PLoS One 14: e0216720, doi: 10.1371/journal.pone.0216720.
Sramkova M, Kozics K, Masanova V, Uhnakova I, Razga F, Nemethova V, Mazancova P, Kapka-Skrzypczak L, Kruszewski M, Novotova M, Puntes VF, Gabelova A (2019): Kidney nanotoxicity studied in human renal proximal tubule epithelial cell line TH1. Mutat Res 845: 403017 doi: 10.1016/j.mrgentox.2019.01.012.
FrontiersPhysiol Cagalinec M, Zahradnikova A, Zahradnikova A Jr, Kovacova D, Paulis L, Kurekova S, Hotka M, Pavelkova J, Plaas M, Novotova M, Zahradnik I (2019). Calcium signaling and contractility in cardiac myocyte of wolframin deficient rats. Front Physiol 10: 172, doi: 10.3389/fphys.2019.00172.
SciRep Ohradanova-Repic A, Machacek C, Donner C, Muhlgrabner V, Petrovcikova E, Zahradnikova A Jr, Vicikova K, Horejsi V, Stockinger H, Leksa V (2019): The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosisy. J Leukoc Biol. 105: 519-530, doi: 10.1002/JLB.1AB0417-160RR.
SciRep Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey MA, Cagalinec M, Mandel M, Zeb A, Liiv M, Kaasik A (2019): Miro proteins prime mitochondria for Parkin translocation and mitophagy. EMBO J 38: e99384, doi: 10.15252/embj.201899384.
SciRep Marcek Chorvatova A, Kirchnerova J, Cagalinec M, Mateasik A, Chorvat D Jr (2019): Spectrally and spatially resolved laser-induced photobleaching of endogenous flavin fluorescence in cardiac myocytes. Cytometry Part A 95: 13-23, doi: 10.1002/cyto.a.23591.
SciRep Prola A, Nichtova Z, Pires Da Silva J, Piquereau J, Monceaux K, Guilbert A, Gressette M, Ventura-Clapier R, Garnier A, Zahradnik I, Novotova M, Lemaire C (2019): Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes. Cardiovasc Res 115: 328-342, doi: 10.1093/cvr/cvy197.
SciRep Martinkova N, Pikula J, Zukal J, Kovacova V, Bandouchova H, Bartonicka T, Botvinkin AD, Brichta J, Dundarova H, Kokurewicz T, Irwin NR, Linhart P, Orlov OL, Piacek V, Skrabanek P, Tiunov MP, Zahradnikova A Jr (2018): Hibernation temperature-dependent Pseudogymnoascus destructans infection intensity in Palearctic bats. Virulence 9: 1734-1750.
SciRep Harazim M, Horacek I, Jakesova L, Luermann K, Moravec JC, Morgan S, Pikula J, Sosik P, Vavrusova Z, Zahradnikova A Jr, Zukal J, Martinkova N (2018): Natural selection in bats with historical exposure to white-nose syndrome. BMC Zoology 3: 8.
SciRep Bandouchova H, Bartonicka T, Berkova H, Brichta J, Kokurewicz T, Kovacova V, Linhart P, Piacek V, Pikula J, Zahradnikova A Jr, Zukal J (2018): Alterations in the health of hibernating bats under pathogen pressure. Sci Rep 8: 6067.
TransboundEmergDis Zahradnikova A Jr, Kovacova V, Martinkova N, Orlova MV, Orlov OL, Piacek V, Zukal J, Pikula J (2018): Historic and geographic surveillance of Pseudogymnoascus destructans possible from collections of bat parasites. Transbound Emerg Dis 65: 303-308.
PLoSOne Hotka M, Zahradnik I (2017): Reconstruction of membrane current by deconvolution and its application to membrane capacitance measurements in cardiac myocytes. PLoS One 12: e0188452.
Eur Biophys J Mackova K, Zahradnikova A Jr, Hotka M, Hoffmannova B, Zahradnik I, Zahradnikova A (2017). Calcium release-dependent inactivation precedes formation of the tubular system in developing rat cardiac myocytes. Eur Biophys J 46: 691-703.
JCI Insight Wang YY, Mesirca P, Marques-Sule E, Zahradnikova A Jr, Villejoubert O, D’Ocon P, Ruiz C, Domingo D, Zorio E, Mangoni ME, Benitah JP, Gómez AM (2017). RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism. JCI Insight 2: e91872.
FrontiersPhysiol Faltinova A, Tomaskova N, Antalik M, Sevcik J, Zahradnikova A (2017). The N-terminal region of the ryanodine receptor affects channel activation. Front Physiol 8: 443.
PubMed Ragni CV, Diguet N, Le Garrec JF, Novotova M, Resende TP, Pop S, Charon N, Guillemot L, Kitasato L, Badouel C, Dufour A, Olivo-Marin JC, Trouvé A, McNeill H, Meilhac SM. (2017): Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun 27: 14582.
PubMed Misuth M, Joniova J, Horvath D, Dzurova L, Nichtova Z, Novotova M, Miskovsky P, Stroffekova K, Huntosova V. (2017): The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. Cell Signal 34: 11–22.
PubMed Huntosova V, Novotova M, Nichtova Z, Balogova L, Maslanakova M, Petrovajova D, Stroffekova K (2017): Assessing light-independent effects of hypericin on cell viability, ultrastructure and metabolism in human glioma and endothelial cells. Toxicol In Vitro 40: 184–195.