Department of Cellular Cardiology, IEE BRC SLOVENSKY contactcontact

RNDr. Alexandra Zahradníková jr., PhD.


Full CV
List of publications 		photo
      ResearcherID                  

Position:
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovak Republic, Senior Research Fellow

Qualification:
1999 MS, Biology, Animal physiology and ethology, Comenius University, Faculty of natural sciences, Bratislava (supervisor: RNDr. Karol Pachinger, CSc.)
2007 RNDr, Biology, Animal physiology and ethology, Comenius University, Faculty of natural sciences, Bratislava (supervisor: RNDr. Marta Novotova, CSc.)
2010 PhD, Animal Physiology, Pavol Jozef Safarik University, Kosice (supervisor: RNDr. Marta Novotova, CSc.)

Techniques:
  • Confocal microscopy (methods for measuring of calcium dynamics, antibody staining, cell structure staining)
  • Electrophysiology (patch-clamp, planar lipid bilayer)
  • Cell physiology (isolation of rat and mouse ventricular myocytes, isolation of rat neonatal cardiomyocytes)
    Molecular biology (DNA and RNA extraction, PCR, transformation and cultivation of bacteria, transfection and cultivation of neonatal cardiomyocytes, genotyping, Western blot)
  • Animal surgery and diagnostics (minimally invasive transversal aortic banding in mice, ligation of the left anterior descending artery in mice, catheter measurement of P-V loops in left ventricles of mice, mouse echocardiography)
  • Programming (Visual Basic, PHP, Javascript, Lab Talk, Origin C)

Support:

International grants:
image ERA-CVD_JTC2019-055
HF-MetaB – Metabolic therapy of heart failure: which role for B vitamins (2020 – 2024)
principal investigator

Slovak Research and Development Agency (APVV):
image APVV-21-0443
Mitochondrial disease in heart failure (2022 – 2026)
principal investigator
wave APVV-21-0473
Mutations associated with Wolfram syndrome: alternative signaling pathways for calcium and mitochondrial physiology (2022 – 2026)
team member; principal investigator: Michal Cagalinec
image APVV-16-0452
PPIS – Regulation of pericellular proteolysis: From molecular mechanisms to novel immune cell subsets and therapeutic tools (2017-2021)
Principal investigator (IMB SAS): Vladimír Leksa
team leader at IMPG SAS

Grant Agency for Science (VEGA):
image VEGA 2/20182/21
Dyad remodelling in cardiomyocytes in experimental therapy of failing heart (2021 – 2024)
principal investigator