ESF workshop CARDIAC DYNAMICS

International Organizing Committee:

A. Zahradníková (Slovakia), Scientific Organizer

M. Bär (Germany)

B. Echebarria (Spain)

S. Luther (Germany)

I. Zahradník (Slovakia)

Topics

Processes	Mechanisms	Methods	Levels
intracellular calcium dynamics	ion channel gating	experimental	molecular
excitation-contraction coupling	action potential generation	theoretical	cellular
mechano-electric feedback	calcium diffusion and binding		tissue
arrhytmias	spreading of excitation		organ

Themes

• how simplifications of the studied processes implemented into the models affect the veracity of extrapolation into experimentally untested regions of the model parameter space.

• the relative strength of the phenomenological and mechanistic approaches at levels of molecules, cells, tissues and the whole organ

• the advantages and disadvantages of deterministic, stochastic and probabilistic approaches

• the advantages and disadvantages of compartmental vs. reaction-diffusion models

• efficient implementation of the detailed knowledge of molecular and cellular mechanisms to the whole heart models.